Chemical Engineering Division, CSIR-National Chemical Laboratory (CSIR-NCL) Academy of Scientific and Innovative Research (AcSIR), Dr. Homi Bhabha Road, Pune, 411 008, India.
Chem Asian J. 2020 Mar 16;15(6):690-708. doi: 10.1002/asia.201901762. Epub 2020 Feb 17.
Selective hydrogenation of nitriles and alkynes is crucial considering the vast applications of reduced products in industries and in the synthesis of bioactive compounds. Particularly, the late 3d transition metal catalysts (manganese, iron, cobalt, nickel and copper) have shown promising activity for the hydrogenation of nitriles to primary amines, secondary amines and imines. Similarly, semihydrogenation of alkynes to E- and Z-alkenes by 3d metals is adequately successful both via the transfer hydrogenation and by using molecular hydrogen. The emergence of 3d transition metals in the selective synthesis of industrially relevant amines, imines and alkenes makes this protocol more attractive. Herein, we provide a concise overview on the late 3d transition metal-catalyzed hydrogenation of nitriles to amines and imines as well as semihydrogenation of alkynes to alkenes.
考虑到还原产物在工业和生物活性化合物合成中的广泛应用，腈和炔的选择性加氢至关重要。特别是，后 3d 过渡金属催化剂（锰、铁、钴、镍和铜）已显示出对腈氢化为伯胺、仲胺和亚胺的高活性。同样，3d 金属对半氢化炔烃为 E-和 Z-烯烃的反应通过转移氢化和使用分子氢也非常成功。3d 过渡金属在工业相关胺、亚胺和烯烃的选择性合成中的出现使该方法更具吸引力。本文对后 3d 过渡金属催化腈氢化为胺和亚胺以及炔烃半氢化生成烯烃的反应进行了简要概述。
