Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
Department of Big Data, Health Insurance Review Assessment Service, Wonju, Korea.
J Korean Med Sci. 2020 Feb 10;35(5):e35. doi: 10.3346/jkms.2020.35.e35.
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis or pregnancy morbidity in patients with persistent antiphospholipid antibodies. However, nationwide population-based epidemiology studies regarding APS are still unavailable.
We analyzed claims data extracted from the Korean Health Insurance and Review Agency (HIRA) covering more than 52 million Koreans, between January 1, 2008, and December 31, 2017. Patients diagnosed with APS, as determined by the Korean Classification of Disease, 7th edition (D68.6), and a rare intractable disease program (V253), were identified in HIRA.
A total of 3,088 newly diagnosed incident cases of 1,215 men and 1,873 women were identified during 2009-2016. The mean age was 44.6 ± 16.6 (men, 47.4 ± 16.3; women, 42.8 ± 16.6) years. The incidence was 0.75 per 10⁵ person-year (95% confidence interval, 0.73-0.78). The prevalence in 2016 was 6.19 per 10⁵ people. For incident cases, women showed incidence peak at ages of 30-39 years and 70-79 years, whereas for men, it was highest at ages of 70-79 years only. Of all patients, 1,766 (57%, 810 men and 956 women) had primary APS, 1,322 (43%, 405 men and 917 women) had secondary APS, and 845 (27%, 216 men and 629 women) were associated with systemic lupus erythematosus (SLE).
The incidence of APS differs according to age groups and gender. The incidence of primary APS was higher than that of secondary APS in both gender. Furthermore, as already reported, secondary APS is highly associated with SLE; however, we observed that rheumatoid arthritis is also highly related.
抗磷脂综合征（APS）是一种系统性自身免疫性疾病，其特征是在持续存在抗磷脂抗体的患者中出现动脉和静脉血栓形成或妊娠并发症。然而，目前仍缺乏关于 APS 的全国性基于人群的流行病学研究。
我们分析了从韩国健康保险审查和评估服务（HIRA）中提取的 2008 年 1 月 1 日至 2017 年 12 月 31 日期间覆盖超过 5200 万韩国人的理赔数据。APS 患者的诊断是根据韩国疾病分类第 7 版（D68.6）和罕见难治性疾病计划（V253）确定的，在 HIRA 中进行了识别。
在 2009 年至 2016 年期间，共确定了 3088 例新诊断的 1215 名男性和 1873 名女性 APS 病例。平均年龄为 44.6 ± 16.6 岁（男性为 47.4 ± 16.3 岁，女性为 42.8 ± 16.6 岁）。发病率为 0.75/10⁵人年（95%置信区间为 0.73-0.78）。2016 年的患病率为 6.19/10⁵人。对于新发病例，女性在 30-39 岁和 70-79 岁时发病率最高，而男性仅在 70-79 岁时发病率最高。所有患者中，1766 例（57%，810 名男性和 956 名女性）为原发性 APS，1322 例（43%，405 名男性和 917 名女性）为继发性 APS，845 例（27%，216 名男性和 629 名女性）与系统性红斑狼疮（SLE）有关。
APS 的发病率因年龄组和性别而异。男女两性原发性 APS 的发病率均高于继发性 APS。此外，正如已经报道的，继发性 APS 与 SLE 高度相关；然而，我们观察到类风湿关节炎也与 APS 高度相关。
