Khellaf Meheni, Meisner Paul, Sarno Maria, Zaremba Piotr, Jedrzejczyk Adam, Scowcroft Anna
Global Real World Evidence, UCB, Brussels, Belgium.
Life Sciences, Planet Pharma, London, UK.
BMJ Open. 2024 Dec 11;14(12):e084563. doi: 10.1136/bmjopen-2024-084563.
Few epidemiological studies are reported in the published literature on the incidence or prevalence of antiphospholipid syndrome (APS), and available results are heterogeneous. This study aimed to estimate the incidence and prevalence of APS in the USA, overall and by APS subtype.
A retrospective analysis of APS disease incidence and a cross-sectional analysis of disease prevalence.
Merative MarketScan Commercial Claims and Encounters Database, and the Medicare Supplemental and Coordination of Benefits Database.
All individuals with claims for at least two antiphospholipid antibody tests undertaken at least 12 weeks apart and a diagnosis claim for APS as a primary or secondary diagnosis on or after the second antibody test, during the period 1 January 2016 to 31 December 2019.
Annual incidence and prevalence of APS and APS subtypes.
In total, 1708 cases of APS were identified during the study period (2016-2019), of which 83% were women. The overall annual standardised incidence rate of APS per 100 000 person-years increased slightly over the study period, from 2.31 in 2016 to 2.71 in 2019. In 2019, the estimated annual prevalence of APS per 100 000 persons was 10.42 per 100 000 persons (95% CI 9.96-10.90). Based on this and US census data, we have estimated that 34 000 persons in the USA were affected by APS in 2019.
These data add to the estimates of prevalence and incidence of APS in the literature, all of which have different strengths and limitations of the different data sources and case ascertainment methods.
已发表的文献中关于抗磷脂综合征（APS）发病率或患病率的流行病学研究较少，且现有结果存在异质性。本研究旨在估计美国APS的发病率和患病率，包括总体情况以及按APS亚型分类的情况。
对APS疾病发病率进行回顾性分析，对疾病患病率进行横断面分析。
Merative MarketScan商业理赔与诊疗数据库，以及医疗保险补充与福利协调数据库。
在2016年1月1日至2019年12月31日期间，所有进行过至少两次抗磷脂抗体检测且两次检测间隔至少12周，并在第二次抗体检测或之后将APS作为主要或次要诊断的索赔个体。
APS及APS亚型的年发病率和患病率。
在研究期间（2016 - 2019年）共识别出1708例APS病例，其中83%为女性。在研究期间，APS每10万人年的总体年标准化发病率略有上升，从2016年的2.31上升至2019年的2.71。2019年，每10万人中APS的估计年患病率为每10万人10.42（95%可信区间9.96 - 10.90）。基于此及美国人口普查数据，我们估计2019年美国有34000人受APS影响。
这些数据补充了文献中关于APS患病率和发病率的估计，所有这些估计因不同的数据来源和病例确定方法而具有不同的优势和局限性。
