Department of Neurology, West China Hospital, Sichuan University, No. 37, Wainan Guoxue Xiang, Chengdu 610041, Sichuan, China.
Curr Neurovasc Res. 2020;17(2):177-187. doi: 10.2174/1567202617666200207130659.
People with migraine experience cognitive decline more often than healthy controls, resulting in a significant functional impact. Early identifying influencing factors that contribute to cognitive decline in migraineurs is crucial for timely intervention. Although migraine may onset early in childhood and early onset migraine is related to significant disability, there is no research investigating the association between the age of migraine onset and migraineurs' cognitive decline. Therefore we aim to explore possible factors that correlate to the cognitive function of migraineurs, especially focus on age of migraine onset.
531 patients with migraine were included. Data on demographics and headache-related characteristics were collected and evaluated using face-to-face interviews and questionnaires. We used the Montreal Cognitive Assessment scale to assess cognitive function. In addition, we analyzed independent correlations between cognitive decline and the age of migraine onset in patients with migraine. And all patients completed the Headache Impact Test-6 to evaluate their quality of life.
Migraineurs with cognitive decline showed significant differences from those without in age (OR=1.26, P<0.0001), years of education (OR=0.89, P=0.0182), the intensity of headache (OR=1.03, P=0.0217), age of onset (OR=0.92, P<0.0001) and anxiety scores (OR=1.09, P=0.0235). Furthermore, there was no interaction in the age of onset between subgroups. Multivariate linear regression analyses of HIT-6 scores showed that the intensity of headache (β=0.18, P<0.0001) and depression scores (β=0.26, P=0.0009) had independent effects on decreased quality of life.
Our findings suggest that younger age of migraine onset is independently related to migraineurs' cognitive decline, and migraine accompanying anxiety symptoms significantly related to decreased quality of life in migraineurs.
偏头痛患者比健康对照组更容易出现认知能力下降，从而导致显著的功能影响。早期确定导致偏头痛患者认知能力下降的影响因素对于及时干预至关重要。尽管偏头痛可能在儿童早期发作，并且早发性偏头痛与显著的残疾有关，但目前尚无研究调查偏头痛发作年龄与偏头痛患者认知能力下降之间的关系。因此，我们旨在探讨与偏头痛患者认知功能相关的可能因素，特别是关注偏头痛发作年龄。
纳入 531 例偏头痛患者。通过面对面访谈和问卷调查收集并评估患者的人口统计学和头痛相关特征。我们使用蒙特利尔认知评估量表评估认知功能。此外，我们分析了偏头痛患者认知功能下降与偏头痛发作年龄之间的独立相关性。所有患者均完成头痛影响测试-6 以评估其生活质量。
有认知功能下降的偏头痛患者在年龄（OR=1.26，P<0.0001）、受教育年限（OR=0.89，P=0.0182）、头痛强度（OR=1.03，P=0.0217）、偏头痛发作年龄（OR=0.92，P<0.0001）和焦虑评分（OR=1.09，P=0.0235）方面与无认知功能下降的偏头痛患者存在显著差异。此外，在亚组之间，偏头痛发作年龄没有交互作用。HIT-6 评分的多变量线性回归分析显示，头痛强度（β=0.18，P<0.0001）和抑郁评分（β=0.26，P=0.0009）对生活质量下降有独立影响。
我们的研究结果表明，偏头痛发作年龄越小与偏头痛患者的认知能力下降独立相关，并且偏头痛伴随的焦虑症状与偏头痛患者生活质量的下降显著相关。
