牙齿缺失与痴呆症关联的回顾性分析：一项基于人群的配对病例对照研究。
Retrospective analysis of the association between tooth loss and dementia: a population-based matched case-control study.
作者信息
Tsai Y-C, Wang H-J, Wang L-Y, Shaw C-K, Lee Y-P, Lin M-C, Huang C-H
机构信息
Department of dentistry, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
Joint first author, Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Taiwan.
出版信息
Community Dent Health. 2020 Feb 27;37(1):59-64. doi: 10.1922/CDH_4609Tsai06.
OBJECTIVE
To clarify the association between multiple tooth loss and dementia.
BASIC RESEARCH DESIGN
Case-control study based on the claims data from National Health Insurance Research Database (NHIRD). Patients were divided into two groups: the dementia groups and non-dementia group. For each case patient, one control patient was randomly selected and frequency matched by age (per 5 years) and sex. The case group comprised patients newly diagnosed with dementia, and the index date was the the date of dementia diagnosis, which became the baseline for comorbidity and age calculations.
RESULTS
Among the 43,026 individuals, patients with dementia had a significantly higher extraction density at ages 60-69 (p ⟨ 0.0001) and 70-79 (p = 0.04) years compared with control patients.
CONCLUSIONS
This population-based retrospective study demonstrated an association between tooth loss and dementia. Patients in Taiwan with more tooth extraction experience are likely to have an increased risk of dementia.
目的
阐明多颗牙齿缺失与痴呆症之间的关联。
基础研究设计
基于国民健康保险研究数据库（NHIRD）的理赔数据进行病例对照研究。患者被分为两组：痴呆症组和非痴呆症组。对于每例病例患者，随机选择一名对照患者，并按年龄（每5年一组）和性别进行频数匹配。病例组包括新诊断为痴呆症的患者，索引日期为痴呆症诊断日期，该日期成为合并症和年龄计算的基线。
结果
在43,026名个体中，与对照患者相比，痴呆症患者在60 - 69岁（p < 0.0001）和70 - 79岁（p = 0.04）时的拔牙密度显著更高。
结论
这项基于人群的回顾性研究表明牙齿缺失与痴呆症之间存在关联。台湾地区拔牙经历较多的患者患痴呆症的风险可能会增加。
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