Lu Weiyan, Dai Liqun, Wu Gui, Hu Rong
Department of Orthopaedic Trauma, Foot and Ankle Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Department of Musculoskeletal Tumor, Joint Surgery and Sports Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(1):2309499020901891. doi: 10.1177/2309499020901891.
Modified-Krishnan's frailty index (FI) is an FI calculation method developed by Krishnan et al. in 2014. This study aimed to compare the effectiveness and correlation of the FIs from Krishnan and the Canadian study of health and aging (CSHA) in predicting postoperative outcomes of elderly patients with hip fracture.
Based on clinical follow-up and observation, we utilized these two instruments to predict 3-month mortality, hip function, and recovery of daily activities. The area under the curve (AUC) and the Pearson correlation coefficient were used to compare the two scales' predictive validities for postoperative outcomes.
A total of 130 patients were included; 67% female and mean age 77.5 ± 8.5 years. The AUCs of modified-Krishnan's FI (AUC = 0.856; 95% confidence interval (CI) = 0.767-0.945) and the CSHA-FI (AUC = 0.793; 95% CI = 0.652-0.934) were used to compare the effectiveness in predicting patient mortality. The optimal predictive scores were 0.335 and 0.28, respectively. The Pearson correlation analysis showed that the modified-Krishnan's FI correlated with the Japanese Orthopaedic Association hip score (pain, activity, walking ability, and ability for daily living; = -0.249, = 0.005), while the CSHA-FI was not correlated ( = -0.125, = 0.170). The modified-Krishnan's FI ( = -0.415, < 0.001) and the CSHA-FI ( = -0.332, < 0.001) were both significantly correlated with the functional recovery scale score.
The modified-Krishnan's FI and the CSHA-FI were effective in the prediction of postoperative mortality. But the modified-Krishnan's FI was more consistently associated with the recovery of hip function and daily activities at 3 months after the operation than that of the CSHA-FI. The modified-Krishnan's FI was more suitable to utilize for risk stratification, identifying deficits, and predicting recovery capacity in hip fracture patients.
改良克里希南衰弱指数(FI)是克里希南等人于2014年开发的一种FI计算方法。本研究旨在比较克里希南衰弱指数与加拿大健康与老龄化研究(CSHA)衰弱指数在预测老年髋部骨折患者术后结局方面的有效性和相关性。
基于临床随访和观察,我们使用这两种工具来预测3个月死亡率、髋关节功能和日常活动恢复情况。曲线下面积(AUC)和皮尔逊相关系数用于比较两种量表对术后结局的预测效度。
共纳入130例患者;女性占67%,平均年龄77.5±8.5岁。使用改良克里希南衰弱指数的AUC(AUC = 0.856;95%置信区间(CI)= 0.767 - 0.945)和CSHA衰弱指数(AUC = 0.793;95% CI = 0.652 - 0.934)来比较预测患者死亡率的有效性。最佳预测分数分别为0.335和0.28。皮尔逊相关分析表明,改良克里希南衰弱指数与日本骨科协会髋关节评分(疼痛、活动、行走能力和日常生活能力;r = -0.249,P = 0.005)相关,而CSHA衰弱指数不相关(r = -0.125,P = 0.170)。改良克里希南衰弱指数(r = -0.415,P < 0.001)和CSHA衰弱指数(r = -0.332,P < 0.001)均与功能恢复量表评分显著相关。
改良克里希南衰弱指数和CSHA衰弱指数在预测术后死亡率方面有效,但改良克里希南衰弱指数在术后3个月时比CSHA衰弱指数更一致地与髋关节功能和日常活动恢复相关。改良克里希南衰弱指数更适合用于髋部骨折患者的风险分层、识别缺陷和预测恢复能力。