Shimada Atsumi, Ueno Hiroshi, Inagaki Masanori, Yoshimitsu Hitoshi
Division of Food and Nutrition, Nakamura Gakuen University Junior College, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan, Phone: +81-92-851-5494, Fax: +81-92-841-7762.
Department of Medical Technology, Kawasaki University of Medical Welfare, Okayama 701-0193, Japan.
Z Naturforsch C J Biosci. 2020 Jan 28;75(1-2):31-39. doi: 10.1515/znc-2019-0117.
This study aimed to compare the biological activities of 35 herbal hydroethanolic extracts and select high potential extract, which showed antioxidative activity and inhibitory activities of α-glucosidase, lipase, and hyaluronidase, and to investigate the isolation, structural elucidation, and biological activities of five phenolic compounds from the selected extracts of Rosa gallica. On the basis of one-dimensional nuclear magnetic resonance together with the comparison with the literature values, the phenolic compounds were identified as methyl gallate (1), kaempferol-3-O-arabinofuranoside (2), multinoside A acetate (3), kaempferol (4), and quercetin (5), respectively. The results suggest that the extracts from R. gallica show the strongest biological activities in 35 herbal extracts and that 1, 4, and 5 among the five isolated compounds from rose extracts are effective in promoting antioxidative and enzymatic inhibitory activities.
本研究旨在比较35种草药水乙醇提取物的生物活性，并筛选出具有高潜力的提取物，这些提取物表现出抗氧化活性以及对α-葡萄糖苷酶、脂肪酶和透明质酸酶的抑制活性，同时研究从法国蔷薇选定提取物中分离出的5种酚类化合物的结构鉴定及生物活性。基于一维核磁共振并与文献值进行比较，这些酚类化合物分别被鉴定为没食子酸甲酯（1）、山奈酚-3-O-阿拉伯呋喃糖苷（2）、多刺蔷薇苷A乙酸酯（3）、山奈酚（4）和槲皮素（5）。结果表明，法国蔷薇提取物在35种草药提取物中表现出最强的生物活性，并且从玫瑰提取物中分离出的5种化合物中的1、4和5在促进抗氧化和酶抑制活性方面具有效果。
