贝达喹啉和德拉马尼在耐多药结核病患儿中的应用：何为 QTc 延长？
Bedaquiline and Delamanid in Children With XDR Tuberculosis: What is prolonged QTc?
机构信息
From the Pediatric TB Clinic, Department of Pediatric Infectious Diseases, B J Wadia Hospital for Children, Mumbai, India.
出版信息
Pediatr Infect Dis J. 2020 Jun;39(6):512-513. doi: 10.1097/INF.0000000000002601.
Bedaquiline and delamanid used to treat extensively drug-resistant tuberculosis are known to cause prolonged QTc. Two children with extensively drug-resistant tuberculosis were put on bedaquiline and delamanid and had prolonged QTc on the Bazett formula but normal QTc by the Fridericia formula. Both had no adverse effects. Correct formula for monitoring QTc should be used thereby preventing unnecessary withholding of medicines.
贝达喹啉和德拉马尼过去被用于治疗广泛耐药结核病，已知会导致 QT 间期延长。两名患有广泛耐药结核病的儿童服用了贝达喹啉和德拉马尼，Bazett 公式显示 QT 间期延长，但 Fridericia 公式显示 QT 间期正常。两人均无不良反应。应使用正确的公式监测 QT 间期，从而避免不必要地停药。
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