NHLBI 重度哮喘研究计划（SARP3）队列中，基于痰嗜酸性粒细胞+中性粒细胞亚群的临床特征和纵向轨迹。
Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort.
机构信息
Wake Forest University School of Medicine, Winston-Salem, NC.
Penn State College of Medicine, Hershey, Pa.
出版信息
J Allergy Clin Immunol. 2020 Jul;146(1):222-226. doi: 10.1016/j.jaci.2020.01.039. Epub 2020 Feb 5.
Abstract
Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.
摘要
哮喘患者痰液中嗜酸性粒细胞和中性粒细胞同时升高与最低肺功能、更高的医疗保健利用率相关，并且从纵向来看，进一步导致了肺功能的丧失，提示细胞-细胞相互作用或重叠的炎症途径，而单独增加嗜酸性粒细胞或中性粒细胞的效果则较小。
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本文引用的文献
1
Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.年龄和疾病严重程度对哮喘患者全身皮质类固醇反应的影响。
Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. doi: 10.1164/rccm.201607-1453OC.
2
Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils.重度哮喘的急性加重风险通过痰液嗜酸性粒细胞的纵向测量，按炎症表型进行分层。
Clin Exp Allergy. 2016 Oct;46(10):1291-302. doi: 10.1111/cea.12762. Epub 2016 Jun 27.
3
Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.气道疾病个性化治疗分型（ADEPT）研究中哮喘特征和生物标志物的纵向稳定性
Respir Res. 2016 Apr 23;17:43. doi: 10.1186/s12931-016-0360-5.
4
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis.聚类分析显示，痰中性粒细胞计数与更严重的哮喘表型相关。
J Allergy Clin Immunol. 2014 Jun;133(6):1557-63.e5. doi: 10.1016/j.jaci.2013.10.011. Epub 2013 Dec 9.
5
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.一大亚组轻中度哮喘持续为非嗜酸性粒细胞性。
Am J Respir Crit Care Med. 2012 Mar 15;185(6):612-9. doi: 10.1164/rccm.201109-1640OC. Epub 2012 Jan 20.
6
Expiratory flows and airway inflammation in elderly asthmatic patients.老年哮喘患者的呼气流量和气道炎症。
Respir Med. 2011 Sep;105(9):1284-9. doi: 10.1016/j.rmed.2011.04.006. Epub 2011 May 4.
7
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.根据痰中粒细胞对哮喘严重程度表型和炎症蛋白进行分析。
J Allergy Clin Immunol. 2010 May;125(5):1028-1036.e13. doi: 10.1016/j.jaci.2010.02.008. Epub 2010 Apr 15.
8
Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples.接受皮质类固醇治疗的哮喘患者痰液炎症细胞的变异性：一项使用多个样本的前瞻性研究。
J Allergy Clin Immunol. 2010 May;125(5):1161-1163.e4. doi: 10.1016/j.jaci.2010.02.005. Epub 2010 Apr 14.
9
Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study.难治性哮喘患者痰液嗜酸性粒细胞增多的一致性：一项5年随访研究
J Allergy Clin Immunol. 2009 Sep;124(3):615-7, 617.e1-2. doi: 10.1016/j.jaci.2009.06.029.
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