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NHLBI 重度哮喘研究计划（SARP3）队列中，基于痰嗜酸性粒细胞+中性粒细胞亚群的临床特征和纵向轨迹。

Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort.

机构信息

Wake Forest University School of Medicine, Winston-Salem, NC.

Penn State College of Medicine, Hershey, Pa.

出版信息

J Allergy Clin Immunol. 2020 Jul;146(1):222-226. doi: 10.1016/j.jaci.2020.01.039. Epub 2020 Feb 5.

DOI:10.1016/j.jaci.2020.01.039
PMID:32032631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7343602/
Abstract

Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.

摘要

哮喘患者痰液中嗜酸性粒细胞和中性粒细胞同时升高与最低肺功能、更高的医疗保健利用率相关，并且从纵向来看，进一步导致了肺功能的丧失，提示细胞-细胞相互作用或重叠的炎症途径，而单独增加嗜酸性粒细胞或中性粒细胞的效果则较小。

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