合成疏水性聚氨基酸的静电纺丝及纺丝后链构象

Electrospinning and Post-Spun Chain Conformations of Synthetic, Hydrophobic Poly(-amino acid)s.

作者信息

Devarayan Kesavan, Nakagami Souta, Suzuki Shuichi, Yuki Ichiro, Ohkawa Kousaku

机构信息

Department of Basic Sciences, College of Fisheries Engineering, Tamil Nadu Dr. J. Jayalalithaa Fisheries University, Vettar River View Campus, Nagapattinam 611 002, India.

Division of Synthetic Polymers, Institute of High Polymer Research, Faculty of Textile Science and Technology, Shinshu University, Tokida 3-15-1, Ueda 386-8567, Japan.

出版信息

Polymers (Basel). 2020 Feb 4;12(2):327. doi: 10.3390/polym12020327.

DOI:10.3390/polym12020327

PMID:32033154

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7077440/

Abstract

Electrospinning and post-spun conformations of hydrophobic poly(-amino acid)s are described in this study. The poly(-amino acid)s, poly(Gly), poly(L-Ala), poly(L-Val), and poly(L-Leu) were synthesized via corresponding -carboxy--amino acid anhydrides. The average molecular weight and degree of polymerization of these polymers were determined by -terminus labeling using 2,4-dinitrofluorobenzene and by viscometry in the case of poly(Gly). These poly(-amino acid)s were electrospun from trifluoroacetic acid or trifluoroacetic acid/dichloromethane solutions. The FT-IR spectroscopy and wide-angle X-ray diffraction indicated that the electrospun poly(L-Ala) and poly(L-Leu) fibers predominantly adopts -helical structure, whereas poly(L-Val) and poly(Gly) fibers exhibited mainly -strand and random coil structures, respectively.

摘要

本研究描述了疏水性聚氨基酸的静电纺丝及纺丝后构象。聚氨基酸聚甘氨酸、聚L-丙氨酸、聚L-缬氨酸和聚L-亮氨酸通过相应的α-羧基-α-氨基酸酐合成。这些聚合物的平均分子量和聚合度通过使用2,4-二硝基氟苯的α-末端标记法测定，聚甘氨酸的情况则通过粘度测定法测定。这些聚氨基酸从三氟乙酸或三氟乙酸/二氯甲烷溶液中静电纺丝。傅里叶变换红外光谱和广角X射线衍射表明，静电纺丝的聚L-丙氨酸和聚L-亮氨酸纤维主要采用α-螺旋结构，而聚L-缬氨酸和聚甘氨酸纤维分别主要呈现β-折叠链和无规卷曲结构。