ACS Appl Mater Interfaces. 2010 Oct;2(10):2728-32. doi: 10.1021/am1006657.
Water-insoluble nanofiber mats of synthetic polypeptides of defined composition have been prepared by a process involving electrospinning from aqueous solution. L-ornithine is a physiological amino acid. Fibers of poly(L-ornithine) (PLO) were produced at feedstock concentrations above 20% w/v. Applied voltage and needle-to-collector distance were crucial for nanofiber formation. Attractive fibers were obtained at 35-40% w/v. Fiber diameter and mat morphology have been characterized by electron microscopy. Polymer cross-linking with glutaraldehyde (GTA) vapor rendered fiber mats water-insoluble. The study has yielded two advances on previous work in the area: avoidance of an animal source of peptides and avoidance of inorganic solvent.
已经通过涉及从水溶液中电纺丝的过程制备了具有确定组成的合成多肽的水不溶性纳米纤维垫。L-鸟氨酸是一种生理氨基酸。在进料浓度高于 20％w/v 时生产聚（L-鸟氨酸）（PLO）纤维。施加电压和针与收集器之间的距离对于纳米纤维的形成至关重要。在 35-40％w/v 时获得了有吸引力的纤维。通过电子显微镜对纤维直径和垫形态进行了表征。用戊二醛（GTA）蒸气对聚合物进行交联，使纤维垫不溶于水。该研究在该领域的先前工作中取得了两项进展：避免了肽的动物来源和避免了无机溶剂。
