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用于牙科修复材料的多功能生物活性树脂

Multifunctional Bioactive Resin for Dental Restorative Materials.

作者信息

Tammaro Loredana, Salle Anna Di, Calarco Anna, Luca Ilenia De, Riccitiello Francesco, Peluso Gianfranco, Vittoria Vittoria, Sorrentino Andrea

机构信息

Nanomaterials and Devices Laboratory (SSPT-PROMAS-NANO), Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, P.le E. Fermi 1, 80055 Portici (Na), Italy.

Research Institute on Terrestrial Ecosystems (IRET)-CNR, via P. Castellino 111, 80131 Napoli, Italy.

出版信息

Polymers (Basel). 2020 Feb 5;12(2):332. doi: 10.3390/polym12020332.

DOI:10.3390/polym12020332
PMID:32033310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7077377/
Abstract

Resin-based composites are widely used as dental restorative materials due to their excellent properties. They must have high modulus, high hardness, and be chemically inert while minimizing moisture uptake. To fulfill these higher standard prerequisites and properties, continuous improvements in each of their components are required. This study develops novel composites with multiple biofunctions. Light-cured Bis-GMA/TEGDMA dental resin (RK)/layered double hydroxide intercalated with fluoride ions (LDH-F)/calcium bentonite (Bt) hybrid composites were prepared. The loading ratio of LDH-F to Bt was varied, ranging from 2.5/2.5 to 10/10 parts per hundred RK and structural, mechanical, and biological properties were studied. The incorporation of even small mass fractions (e.g., 2.5 wt % of LDH-F and 2.5 wt % of Bt) in RK dental resin significantly improved the mechanical properties of the pristine resin. The synthetized materials showed antibacterial and antibiofilm effects against three bacterial strains isolated from healthy volunteers' saliva ( spp., , and ) without affecting its ability to induce dental pulp stem cells differentiation into odontoblast-like cells. The capability to balance between the antibiofilm activity and dental pulp stem cells differentiation in addition with improved mechanical properties make these materials a promising strategy in preventive and restorative dentistry.

摘要

基于树脂的复合材料因其优异的性能而被广泛用作牙科修复材料。它们必须具有高模量、高硬度，并且在尽量减少水分吸收的同时具有化学惰性。为了满足这些更高标准的先决条件和性能要求，需要对其每个组分进行持续改进。本研究开发了具有多种生物功能的新型复合材料。制备了光固化双酚A-甲基丙烯酸缩水甘油酯/三乙二醇二甲基丙烯酸酯牙科树脂（RK）/插层有氟离子的层状双氢氧化物（LDH-F）/钙膨润土（Bt）混杂复合材料。改变LDH-F与Bt的负载比，范围为每百份RK中2.5/2.5至10/10份，并研究了其结构、力学和生物学性能。在RK牙科树脂中加入甚至少量的质量分数（例如2.5 wt%的LDH-F和2.5 wt%的Bt）就能显著改善原始树脂的力学性能。合成材料对从健康志愿者唾液中分离出的三种细菌菌株（ 菌、 菌和 菌）显示出抗菌和抗生物膜作用，同时不影响其诱导牙髓干细胞分化为成牙本质样细胞的能力。除了改善力学性能外，在抗生物膜活性和牙髓干细胞分化之间取得平衡的能力使这些材料成为预防和修复牙科领域一种有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/284294c25235/polymers-12-00332-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/63e152337910/polymers-12-00332-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/c8dc4353cbf1/polymers-12-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/553446b2c0e4/polymers-12-00332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/0bdcd7d46ab4/polymers-12-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/7e00dfd94846/polymers-12-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/0701d494a0bb/polymers-12-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/bc332bb4b9e8/polymers-12-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/26c301742080/polymers-12-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/49777a525169/polymers-12-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/2dabfc4c0ff4/polymers-12-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/009975867532/polymers-12-00332-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/f7f3891278d2/polymers-12-00332-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/91ec4795bd18/polymers-12-00332-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/284294c25235/polymers-12-00332-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/63e152337910/polymers-12-00332-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/c8dc4353cbf1/polymers-12-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/553446b2c0e4/polymers-12-00332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/0bdcd7d46ab4/polymers-12-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/7e00dfd94846/polymers-12-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/0701d494a0bb/polymers-12-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/bc332bb4b9e8/polymers-12-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/26c301742080/polymers-12-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/49777a525169/polymers-12-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/2dabfc4c0ff4/polymers-12-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/009975867532/polymers-12-00332-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/f7f3891278d2/polymers-12-00332-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/91ec4795bd18/polymers-12-00332-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/7077377/284294c25235/polymers-12-00332-g013.jpg

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