Faculté de Médecine et des Sciences de la Santé, Department of Immunology and Cell Biology, Université de Sherbrooke, 3201 Rue Jean Mignault, Sherbrooke, QC J1E 4K8, Canada.
Int J Mol Sci. 2020 Feb 5;21(3):1064. doi: 10.3390/ijms21031064.
Rab GTPases play key roles in various cellular processes. They are essential, among other roles, to membrane trafficking and intracellular signaling events. Both trafficking and signaling events are crucial for proper embryonic development. Indeed, embryogenesis is a complex process in which cells respond to various signals and undergo dramatic changes in their shape, position, and function. Over the last few decades, cellular studies have highlighted the novel signaling roles played by Rab GTPases, while numerous studies have shed light on the important requirements of Rab proteins at various steps of embryonic development. In this review, we aimed to generate an overview of Rab contributions during animal embryogenesis. We first briefly summarize the involvement of Rabs in signaling events. We then extensively highlight the contribution of Rabs in shaping metazoan development and conclude with new approaches that will allow investigation of Rab functions in vivo.
Rab GTPases 在各种细胞过程中发挥关键作用。它们在膜运输和细胞内信号事件等方面起着至关重要的作用。运输和信号事件对于胚胎的正常发育都是至关重要的。事实上，胚胎发生是一个复杂的过程，在此过程中，细胞会对各种信号做出反应，并在形状、位置和功能上发生剧烈变化。在过去的几十年中，细胞研究强调了 Rab GTPases 发挥的新信号作用，同时许多研究也揭示了 Rab 蛋白在胚胎发育的各个阶段的重要需求。在这篇综述中，我们旨在概述 Rab 在动物胚胎发生过程中的作用。我们首先简要总结了 Rab 参与信号事件的情况。然后，我们重点介绍了 Rab 在塑造后生动物发育中的作用，并以新的方法结束，这些方法将允许在体内研究 Rab 的功能。
