Zhao Erhu, Hou Jianbing, Cui Hongjuan
State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing, 400716, China.
Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Oncogenesis. 2020 Feb 7;9(2):14. doi: 10.1038/s41389-020-0200-9.
In a recent study published in Cancer Research, Xia and colleagues reported that, in cancer, constituents in serine-glycine-one-carbon (SGOC) metabolism exhibit enhanced transcriptional activation and are increasingly utilised, which results in more glucose-derived carbon to serine-glycine biosynthesis. The current work identifies an MYCN-dependent metabolic vulnerability and shows a variety of associations between metabolic reprogramming and enhanced sensitivity to metabolic stress, which may lead the way to unlocking new anticancer therapies. Here, we summarised new insights into the role of SGOC metabolism in the progression of neuroblastoma (NB) with highly activated SGOC metabolism.
在最近发表于《癌症研究》的一项研究中，夏及其同事报告称，在癌症中，丝氨酸-甘氨酸-一碳（SGOC）代谢中的成分表现出增强的转录激活作用，且其利用率不断提高，这导致更多源自葡萄糖的碳用于丝氨酸-甘氨酸的生物合成。当前的研究确定了一种MYCN依赖性的代谢脆弱性，并显示出代谢重编程与对代谢应激的敏感性增强之间存在多种关联，这可能为开发新的抗癌疗法指明方向。在此，我们总结了关于SGOC代谢在具有高度激活的SGOC代谢的神经母细胞瘤（NB）进展中的作用的新见解。
