Ge Mingpai, Xu Yuan, Cui Lu, Huang Enyuan, Liu Zhaorui, Yin Kai
Department of Gastrointestinal Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.
Front Oncol. 2025 Jun 4;15:1582116. doi: 10.3389/fonc.2025.1582116. eCollection 2025.
Tumor cells undergo profound metabolic reprogramming to sustain their rapid growth and proliferation, with amino acids serving as essential nutrients critical for protein synthesis, energy metabolism, nucleotide production, and redox balance. The increased reliance of tumor cells on specific amino acids represents a promising therapeutic target. This review provides an in-depth analysis of the biological roles of amino acids in cancer, identifies vulnerabilities associated with amino acid dependency, and discusses strategies to leverage these weaknesses for enhanced cancer treatment. We explore the mechanisms governing amino acid uptake, utilization, and metabolism in tumor cells, as well as their interactions with the tumor microenvironment. Additionally, the review addresses the challenges and prospects of targeting amino acid metabolism in cancer therapy, including issues of resistance, the complexity of metabolic pathways, and the potential for personalized treatment approaches.
肿瘤细胞会经历深刻的代谢重编程以维持其快速生长和增殖，氨基酸作为对蛋白质合成、能量代谢、核苷酸生成和氧化还原平衡至关重要的必需营养素。肿瘤细胞对特定氨基酸的依赖性增加是一个很有前景的治疗靶点。本综述深入分析了氨基酸在癌症中的生物学作用，确定了与氨基酸依赖性相关的脆弱性，并讨论了利用这些弱点来加强癌症治疗的策略。我们探讨了肿瘤细胞中氨基酸摄取、利用和代谢的调控机制，以及它们与肿瘤微环境的相互作用。此外，该综述还阐述了癌症治疗中靶向氨基酸代谢所面临的挑战和前景，包括耐药性问题、代谢途径的复杂性以及个性化治疗方法的潜力。
