Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Department of Prevention and Health Protection, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Neurotox Res. 2020 Apr;37(4):936-943. doi: 10.1007/s12640-020-00171-7. Epub 2020 Feb 8.
Elevated serum uric acid (SUA) has been reported to be associated with an increased risk of cardiovascular diseases, but the role of SUA in intracranial atherosclerosis remains unclear. To investigate the association between SUA and intracranial atherosclerotic stenosis (ICAS), we evaluated 1522 subjects (305 with ICAS, 1217 without ICAS) with magnetic resonance angiography (MRA). Subjects were classified into ten groups according to the deciles of the SUA level. The rate of ICAS reached a minimum in the seventh decile (6.0-6.3 mg/dL; reference group). After adjusting for confounding factors, multivariate logistic regression analysis demonstrated that both low SUA level (≤ 3.8 mg/dL; OR, 2.34; 95% CI, 1.29-4.39; p = 0.006) and high SUA level (≥ 7.8 mg/dL; OR, 2.10; 95% CI, 1.15-3.92; p = 0.017) conferred greater risk for ICAS. In multivariable analysis with a quadratic model which used SUA as a continuous variable, a U-shaped association between SUA and the rate of ICAS was confirmed (α > 0; p < 0.001). The estimated SUA level associated with the lowest rate of ICAS was 6.2 mg/dL. In conclusion, our findings suggest a U-shaped association between ICAS and SUA.
血清尿酸（SUA）水平升高与心血管疾病风险增加有关，但 SUA 与颅内动脉粥样硬化的关系尚不清楚。为了研究 SUA 与颅内动脉粥样硬化性狭窄（ICAS）之间的关系，我们对 1522 例接受磁共振血管造影（MRA）检查的受试者进行了评估（305 例有 ICAS，1217 例无 ICAS）。受试者根据 SUA 水平的十分位数分为十组。ICAS 发生率在第七个十分位数（6.0-6.3 mg/dL；参考组）达到最低。在调整混杂因素后，多变量 logistic 回归分析表明，低 SUA 水平（≤3.8 mg/dL；OR，2.34；95%CI，1.29-4.39；p=0.006）和高 SUA 水平（≥7.8 mg/dL；OR，2.10；95%CI，1.15-3.92；p=0.017）均与 ICAS 的发生风险增加相关。在使用 SUA 作为连续变量的二次模型的多变量分析中，SUA 与 ICAS 发生率之间呈 U 形关联（α>0；p<0.001）。与 ICAS 发生率最低相关的估计 SUA 水平为 6.2 mg/dL。综上所述，本研究结果提示 ICAS 与 SUA 之间呈 U 形关联。
