韩国人群血清尿酸与颅内动脉狭窄之间的关联：基于横断面研究的二次分析
Association Between Serum Uric Acid and Intracranial Arterial Stenosis in a Korean Population: A Secondary Analysis Based on a Cross-Sectional Study.
作者信息
Yao Taotao, Di Anqi, Li Jialing, Zhang Shuchen, He Jun, Xu Nuo, Xu Danghan
机构信息
Rehabilitation Centre, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Ultrasound, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, Yancheng, China.
出版信息
Front Neurol. 2022 Mar 11;13:791456. doi: 10.3389/fneur.2022.791456. eCollection 2022.
BACKGROUND AND PURPOSE
Intracranial arterial stenosis (ICAS) is a common cause of cerebrovascular disease. Studies have shown that the disease may be associated with elevated serum uric acid. However, the results remain inexact and controversial. To provide theoretical support for clinical practice, we assessed the relationship between uric acid and ICAS based on previous literature.
MATERIALS AND METHODS
A total of 1,011 samples were included in the secondary cross-sectional study we investigated. We evaluated the relationship between uric acid level and ICAS using multivariable logistic regression analysis.
RESULTS
The mean age of patients was 64.16 ± 9.13 years, and 35.51% ( = 359) were male in the study. One hundred and one (10%) of the included participants had ICAS. In the unadjusted model, uric acid level was positively associated with ICAS [odds ratio (OR) = 1.23, 95% confidence interval (CI): 1.07-1.42, < 0.01]. After adjusting for potential confounders (sex, age, diabetes mellitus, coronary artery occlusive disease, hyperlipidemia, statin medication, hypertension, and fasting glucose), a positive relationship was observed between uric acid and ICAS (OR = 1.26, 95% CI: 1.08-1.47, < 0.05).
CONCLUSION
There was a positive relationship between uric acid levels and ICAS in neurologically healthy Korean participants.
背景与目的
颅内动脉狭窄（ICAS）是脑血管疾病的常见病因。研究表明，该疾病可能与血清尿酸升高有关。然而，结果仍不确切且存在争议。为临床实践提供理论支持，我们基于既往文献评估了尿酸与ICAS之间的关系。
材料与方法
我们所开展的二次横断面研究共纳入了1011份样本。我们使用多变量逻辑回归分析评估尿酸水平与ICAS之间的关系。
结果
研究中患者的平均年龄为64.16±9.13岁，男性占35.51%（n = 359）。纳入的参与者中有101人（10%）患有ICAS。在未调整模型中，尿酸水平与ICAS呈正相关[比值比（OR）= 1.23，95%置信区间（CI）：1.07 - 1.42，P < 0.01]。在调整潜在混杂因素（性别、年龄、糖尿病、冠状动脉闭塞性疾病、高脂血症、他汀类药物治疗、高血压和空腹血糖）后，观察到尿酸与ICAS之间存在正相关（OR = 1.26，95% CI：1.08 - 1.47，P < 0.05）。
结论
在神经功能正常的韩国参与者中，尿酸水平与ICAS之间存在正相关。
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