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本文引用的文献

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Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases.1 至 3 岁时的过敏致敏和特应性皮炎模式：对过敏性疾病的影响。
Clin Exp Allergy. 2018 Jan;48(1):48-59. doi: 10.1111/cea.13063. Epub 2017 Dec 15.
2
Early-onset atopic dermatitis in children: which are the phenotypes at risk of asthma? Results from the ORCA cohort.儿童早发型特应性皮炎：哪些表型有患哮喘的风险？来自ORCA队列的结果。
PLoS One. 2015 Jun 24;10(6):e0131369. doi: 10.1371/journal.pone.0131369. eCollection 2015.
3
The natural course of sensitization and allergic diseases from childhood to adulthood.从儿童期到成年期致敏和过敏性疾病的自然病程。
Pediatr Allergy Immunol. 2013 Sep;24(6):549-55. doi: 10.1111/pai.12108. Epub 2013 Jul 31.
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Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants.特应性皮炎和疾病严重程度是纯母乳喂养婴儿食物致敏的主要危险因素。
J Invest Dermatol. 2014 Feb;134(2):345-350. doi: 10.1038/jid.2013.298. Epub 2013 Jul 18.
5
Validation of a parental questionnaire to identify atopic dermatitis in a population-based sample of children up to 2 years of age.验证一种父母用问卷识别 2 岁以下儿童特应性皮炎的方法。在基于人群的儿童样本中。
Dermatology. 2013;226(3):222-6. doi: 10.1159/000349983. Epub 2013 Jun 19.
6
Cutaneous lymphocyte antigen and α4β7 T-lymphocyte responses are associated with peanut allergy and tolerance in children.皮肤淋巴细胞抗原和 α4β7 T 淋巴细胞反应与儿童花生过敏和耐受相关。
Allergy. 2012 Mar;67(3):336-42. doi: 10.1111/j.1398-9995.2011.02765.x.
7
Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.SPRR2B 基因多态性作为湿疹儿童哮喘的预测因子。
Ann Allergy Asthma Immunol. 2012 Mar;108(3):145-50. doi: 10.1016/j.anai.2012.01.004.
8
High prevalence of aeroallergen sensitization among infants of atopic parents.特应性父母的婴儿中空气过敏原致敏的高患病率。
J Pediatr. 2006 Oct;149(4):505-11. doi: 10.1016/j.jpeds.2006.06.035.

特应性皮炎使致敏性高于父母特应性：MPAACH 研究。

Atopic dermatitis independently increases sensitization above parental atopy: The MPAACH study.

机构信息

Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

J Allergy Clin Immunol. 2020 May;145(5):1464-1466. doi: 10.1016/j.jaci.2020.01.041. Epub 2020 Feb 5.

DOI:10.1016/j.jaci.2020.01.041
PMID:32035158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7214219/
Abstract

Early sensitization is ~50% higher in children with atopic dermatitis compared to children from a high-risk allergy cohort with comparable rates of parental atopy. AD may increase sensitization risk over heredity alone.

摘要

与具有相似父母特应性的高过敏风险过敏队列的儿童相比，特应性皮炎儿童的早期致敏率高出约 50%。AD 可能会增加致敏风险，而不仅仅是遗传因素。