Department of Otolaryngology, University of Colorado School of Medicine, 12631 E. 17th Ave., B-205, Aurora, CO, 80045, USA.
Department of Otolaryngology, University of Colorado School of Medicine, 12631 E. 17th Ave., B-205, Aurora, CO, 80045, USA.
Int J Pediatr Otorhinolaryngol. 2020 May;132:109916. doi: 10.1016/j.ijporl.2020.109916. Epub 2020 Jan 30.
We present a pediatric case of benign tumoral melanosis in a cervical lymph node arising from congenital pigmented lesions of the anterior neck. This is the first reported pediatric case not associated with regressed melanoma or trauma. Tumoral melanosis is a rare phenomenon which describes a pigmented lesion like melanoma; however, histology demonstrates melanin-laden macrophages without malignant cells. In the few reported cases, tumoral melanosis has arisen in the skin or lymph node and associated with a regressed melanoma, pigmented basal cell carcinoma or mycosis fungoides. We discuss the pathology of this disease process, and the work up in a pediatric patient.
我们呈现了一例发生于颈部前侧先天性色素病变区域的儿童颈部淋巴结良性肿瘤性黑色素增多症。这是首例报道的与消退性黑色素瘤或外伤无关的儿童病例。肿瘤性黑色素增多症是一种罕见的现象,其描述了一种类似黑色素瘤的色素性病变;然而,组织学显示含有黑色素的巨噬细胞而无恶性细胞。在少数报道的病例中,肿瘤性黑色素增多症发生于皮肤或淋巴结,且与消退性黑色素瘤、色素性基底细胞癌或蕈样真菌病相关。我们讨论了该疾病过程的病理学,并探讨了儿科患者的评估方法。