Division of Dermatology, Washington University in St. Louis, St. Louis, MO, U.S.A.
Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, U.S.A.
Br J Dermatol. 2016 Aug;175(2):391-3. doi: 10.1111/bjd.14474. Epub 2016 Mar 18.
Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but on histology reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases so far, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumour. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique case of extensive tumoral melanosis arising during ipilimumab treatment of in-transit metastases from a previously excised melanoma.
肿瘤性黑变病描述了一种临床上类似于黑色素瘤的色素性病变，但在组织学上显示出密集的黑色素沉着、良性巨噬细胞聚集，没有恶性细胞。在迄今为止报道的少数病例中，肿瘤性黑变病发生在患有消退性黑色素瘤或上皮样肿瘤的患者的皮肤或淋巴结中。作为消退性原发性黑色素瘤的标志物，其发现可能促使对未诊断的局部或转移性疾病进行调查和监测。在这里，我们报告了一个独特的病例，即在先前切除的黑色素瘤的转移灶的伊匹单抗治疗过程中发生广泛的肿瘤性黑变病。
