Freie Universität Berlin, Germany.
Freie Universität Berlin, Germany.
Curr Opin Neurobiol. 2020 Aug;63:1-8. doi: 10.1016/j.conb.2020.01.002. Epub 2020 Feb 6.
Two neurons can only form a synapse if their axonal and dendritic projections meet at the same time and place. While spatiotemporal proximity is necessary for synapse formation, it remains unclear to what extent the underlying positional strategies are sufficient to ensure synapse formation between the right partners. Many neurons readily form synapses with wrong partners if they find themselves at the wrong place or time. Minimally, restricting spatiotemporal proximity can prevent incorrect synapses. Maximally, restricting encounters in time and space could be sufficient to ensure correct partnerships between neurons that can form synapses promiscuously. In this review we explore recent findings on positional strategies during developmental growth that contribute to precise outcomes in brain wiring.
如果两个神经元的轴突和树突投射同时在同一时间和地点相遇，它们才能形成突触。虽然时空接近对于突触形成是必要的，但目前尚不清楚在多大程度上，潜在的位置策略足以确保正确的伙伴之间形成突触。如果神经元处于错误的位置或时间，它们很容易与错误的伙伴形成突触。最低限度地，限制时空接近可以防止错误的突触形成。最大限度地，在时间和空间上限制相遇可能足以确保能够随机形成突触的神经元之间建立正确的伙伴关系。在这篇综述中，我们探讨了发育过程中位置策略的最新发现，这些发现有助于大脑布线的精确结果。
