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高效药代动力学建模工作流程与 MonolixSuite：瑞芬太尼案例研究。

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil.

机构信息

Lixoft, Antony, France.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):198-210. doi: 10.1002/psp4.12500. Epub 2020 Mar 31.

DOI:10.1002/psp4.12500
PMID:32036625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7180005/
Abstract

MonolixSuite is a software widely used for model-based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step-by-step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.

摘要

MonolixSuite 是一款广泛用于基于模型的药物开发的软件。它包含了用于数据可视化、非房室分析、非线性混合效应建模和临床试验模拟的相互关联的应用程序。其主要优点是通过交互式图形界面使用方便、计算速度快，即使对于复杂模型也能有效地进行参数估计。本教程介绍了使用 MonolixSuite 进行药代动力学（PK）建模的分步工作流程，包括如何可视化数据、设置群体 PK 模型、估计参数以及逐步诊断和改进模型。

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