Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, Haidian, China.
Bioengineered. 2020 Dec;11(1):165-174. doi: 10.1080/21655979.2020.1718459.
Advanced colorectal cancer (CRC) is a significant cause of cancer mortality, with a poor prognosis. Here, we identified a novel prognostic signature for predicting survival of advanced CRC. Advanced CRC data were used (training set: n = 267 and validation set: n = 264). The survival analyses were investigated. The functional analysis of the prognostic signature was examined. In this study, our 15-gene signature was established and was an independent prognostic factor of advanced CRC. Stratification analyses also showed that this signature was still powerful for survival prediction in each stratum of age, gender, stage, and metastasis status. In mechanism, our signature involved in DNA replication, DNA damage, and cell cycle. Therefore, our findings suggested that this 15-gene signature has prognostic and predictive value in advanced CRC, which could be further used in personalized therapy for advanced CRC.
晚期结直肠癌（CRC）是癌症死亡的重要原因，预后不良。在这里，我们确定了一个新的预后标志物，用于预测晚期 CRC 的生存情况。使用了晚期 CRC 数据（训练集：n = 267，验证集：n = 264）。进行了生存分析。研究了预后标志物的功能分析。在这项研究中，我们建立了一个 15 基因标志物，是晚期 CRC 的独立预后因素。分层分析还表明，该标志物在年龄、性别、分期和转移状态的每个分层中仍然具有强大的生存预测能力。在机制上，我们的标志物涉及 DNA 复制、DNA 损伤和细胞周期。因此，我们的研究结果表明，该 15 基因标志物在晚期 CRC 中具有预后和预测价值，可进一步用于晚期 CRC 的个体化治疗。
