Department of Pharmaceutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai,India.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Expert Opin Drug Deliv. 2020 Mar;17(3):379-393. doi: 10.1080/17425247.2020.1728251. Epub 2020 Feb 17.
: Multipurpose prevention technologies (MPTs) have the potential to avert multiple concomitant sexual and reproductive health issues in women such as sexually transmitted infections and unintended pregnancy. MPTs incorporate one or more active pharmaceutical ingredients in a single product, which adds more convenience for users and may promote increased adherence. Various vaginal dosage forms/delivery systems have been studied for designing MPTs. However, several challenges remain that are mainly related to requirements of individual drugs or intended multiple applications.: This review focuses on the emerging need and development of vaginal MPTs. It illustrates numerous examples that are currently in the preclinical and clinical development pipeline, highlighting the concept behind vaginal MPTs. The article also highlights the challenges associated with formulation design and development, including regulatory issues that need to be addressed.: Vaginal MPTs present great potential to empower women with novel, efficient, and safe products for protection against sexually transmitted infections and unintended pregnancy. However, several technological issues and regulatory gaps still need to be addressed in order to meet real-world needs.
: 多用途预防技术 (MPTs) 有可能解决女性同时面临的多种性健康和生殖健康问题，如性传播感染和意外怀孕。MPTs 在单一产品中结合了一种或多种活性药物成分，为使用者提供了更多的便利，并且可能提高了患者的用药依从性。已经研究了各种阴道剂型/给药系统来设计 MPTs。然而，仍然存在一些主要与个别药物要求或预期的多种应用相关的挑战。: 本综述重点介绍了阴道 MPTs 的新出现的需求和发展。它列举了目前处于临床前和临床开发阶段的众多实例，强调了阴道 MPTs 的概念。文章还强调了与配方设计和开发相关的挑战，包括需要解决的监管问题。: 阴道 MPTs 为女性提供了新型、高效和安全的产品，以预防性传播感染和意外怀孕，具有巨大的潜力。然而，为了满足实际需求，仍需要解决一些技术问题和监管空白。
