Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
Food Res Int. 2020 Mar;129:108792. doi: 10.1016/j.foodres.2019.108792. Epub 2019 Nov 21.
Obesity and diabetes have been increasing at an alarming rate worldwide. Studies have shown the futility of chemical drugs in the treatment of obesity and diabetes. Bifidobacterium longum (BL), a common member of the gut microbiota throughout the human lifespan, has been widely reported to play a role in host health and disease. Here, we evaluated the effects of inactivated cells of BL (IBL) on obesity and blood glucose levels in TSOD mice by administering IBL orally for 5 weeks. The treated mice showed a significant decrease of body weight gain, adipose tissue mass and blood glucose levels, as well as a significant reduction in blood glucose during an oral glucose tolerance test. The treatment also resulted in reduced levels of cholesterol, triglycerides, and NEFA. Moreover, serum and urine analysis showed low creatinine levels in IBL-treated mice. These data demonstrate that IBL may have the potential to prevent obesity and diabetes.
肥胖症和糖尿病在全球范围内呈惊人的速度增长。研究表明，化学药物在肥胖症和糖尿病的治疗中收效甚微。长双歧杆菌（BL）是人类整个生命周期中肠道微生物群的常见成员，已被广泛报道在宿主健康和疾病中发挥作用。在这里，我们通过口服给予 BL 灭活细胞（IBL）5 周，评估 IBL 对 TSOD 小鼠肥胖和血糖水平的影响。经过治疗的小鼠体重增加、脂肪组织质量和血糖水平显著下降，口服葡萄糖耐量试验期间的血糖也显著降低。治疗还导致胆固醇、甘油三酯和非酯化脂肪酸水平降低。此外，血清和尿液分析显示 IBL 治疗的小鼠肌酐水平较低。这些数据表明，IBL 可能具有预防肥胖症和糖尿病的潜力。
