Department of Oral and Maxillofacial Implantology, Tokyo Dental College.
Oral Health Science Center, Tokyo Dental College.
Dent Mater J. 2020 Aug 2;39(4):670-677. doi: 10.4012/dmj.2019-187. Epub 2020 Feb 7.
The aim of this study was clarify the effects of reducing various functional pressures essential for the maintenance of bone homeostasis. Femoral bone mineral density (BMD) and biological apatite (BAp) crystallite alignment were measured in conventionally reared and hindlimb-unloaded mice. The femur was divided into 10 equal segments perpendicular to the longitudinal axis of the bone and measurements were performed on the cortical bone in the five segments closest to the midpoint of the femur. Significantly lower BMD and BAp alignment in the longitudinal (Z-axis) direction were observed in the hindlimb-unloaded group. The present findings suggest that unloading by tail suspension significantly decreases not only mouse femoral bone mass but also BAp crystallite alignment, although minimal uniaxial preferential alignment is retained.
本研究旨在阐明减少维持骨内稳态所必需的各种功能压力的影响。在常规饲养和后肢去负荷的小鼠中测量股骨骨矿物质密度（BMD）和生物磷灰石（BAp）微晶排列。将股骨沿垂直于骨长轴的方向等分为 10 个相等的节段，并在距股骨中点最近的 5 个节段的皮质骨上进行测量。后肢去负荷组的 BMD 和 BAp 在纵向（Z 轴）方向的排列明显降低。本研究结果表明，尽管保留了最小的单轴择优取向，但尾部悬吊引起的去负荷不仅显著降低了小鼠股骨的骨量，而且还降低了 BAp 微晶的排列。
