Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
Core Research for Evolutional Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
J Bone Miner Metab. 2021 Jan;39(1):34-44. doi: 10.1007/s00774-020-01145-7. Epub 2020 Sep 5.
Receptor activator of nuclear factor-κB ligand (RANKL) is a key mediator of osteoclast differentiation and bone resorption. Osteoblast-lineage cells including osteoblasts and osteocytes express RANKL, which is regulated by several different factors, including hormones, cytokines, and mechanical forces. In vivo and in vitro analyses have demonstrated that various types of mechanosensing proteins on the cell membrane (i.e. mechanosensors) and intracellular mechanosignaling proteins play essential roles in the differentiation and functions of osteoblasts, osteoclasts, and osteocytes via soluble factors, such as sclerostin, Wnt ligands, and RANKL. This section provides an overview of the in vivo and in vitro evidence for the regulation of RANKL expression by mechanosensing and mechanotransduction.
核因子-κB 受体激活物配体（RANKL）是破骨细胞分化和骨吸收的关键介质。成骨细胞谱系细胞包括成骨细胞和骨细胞表达 RANKL，其受多种不同因素的调节，包括激素、细胞因子和机械力。体内和体外分析表明，细胞膜上的各种类型的机械感觉蛋白（即机械感受器）和细胞内机械信号蛋白通过可溶性因子（如硬化素、Wnt 配体和 RANKL）在成骨细胞、破骨细胞和骨细胞的分化和功能中发挥重要作用。本节概述了机械感觉和机械转导调节 RANKL 表达的体内和体外证据。
