Clinical Epidemiology & Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Canada.
Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Transfusion. 2020 Mar;60(3):582-587. doi: 10.1111/trf.15695. Epub 2020 Feb 10.
As research surrounding cell-based regenerative therapy advances toward human trials, greater demand for cell products sourced from healthy donors will arise. The extent to which volunteers in Canadian Blood Services Stem Cell Registry would be willing to donate cells to support regenerative therapy is not known and warrants exploration.
We conducted a Web-based survey to assess factors that would influence donor willingness to donate various tissues (blood, skin, fat, and bone marrow) for regenerative therapy. The survey was provided to 15,000 randomly selected donors who registered between 2013 and 2018. Data from the 1118 respondents were analyzed.
Despite a mixed degree of familiarity with regenerative medicine, potential donors were very supportive of donating for direct patient care and for research, and increasing their familiarity by reading a brief paragraph of information on regenerative medicine increased willingness to donate. Canadian Blood Services' stem cell registrants greatly preferred supporting nonprofit groups in research and development in comparison to entities that represent profit-seeking industry involvement. The most important factors influencing donor willingness to donate were having an impact on patients, safety of donation, advancing knowledge in regenerative medicine, a manageable time commitment, and tolerable pain that could be managed. Donors were most willing to donate blood and had mixed responses to donating other tissue types.
Adult volunteers from a national stem cell registry are willing to support donation of biospecimens for regenerative therapy.
随着细胞再生治疗的研究不断推进到人体试验阶段，对来自健康供体的细胞产品的需求将会增加。加拿大血液服务中心干细胞登记处的志愿者愿意捐献细胞来支持再生治疗的程度尚不清楚，值得探讨。
我们进行了一项基于网络的调查，以评估影响供体愿意为再生治疗捐献各种组织（血液、皮肤、脂肪和骨髓）的因素。该调查提供给了 2013 年至 2018 年间注册的 15000 名随机选择的捐赠者。对 1118 名受访者的数据进行了分析。
尽管对再生医学的熟悉程度参差不齐，但潜在的捐赠者非常支持为直接患者护理和研究捐赠，并且通过阅读一段关于再生医学的简短信息来增加他们的熟悉度，增加了捐赠的意愿。与代表寻求利润的行业参与的实体相比，加拿大血液服务中心的干细胞登记处的参与者更倾向于支持非营利组织的研究和开发。影响捐赠者捐赠意愿的最重要因素是对患者产生影响、捐赠的安全性、再生医学知识的进步、可管理的时间承诺和可管理的疼痛。捐赠者最愿意捐献血液，而对捐献其他组织类型的反应则不一。
来自国家干细胞登记处的成年志愿者愿意支持为再生治疗捐献生物样本。
