槟榔、细胞内活性氧与自噬之间的关系
[Relationship among areca nut, intracellular reactive oxygen species, and autophagy].
作者信息
Xu Zhi, Lü Feng-Yuan, Jiang Er-Hui, Zhao Xiao-Ping, Shang Zheng-Jun
机构信息
Dept. of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Feb 1;38(1):80-85. doi: 10.7518/hxkq.2020.01.014.
Abstract
The relationship between areca nut as a primary carcinogen and oral cancer has been widely concerned. Areca can change the levels of reactive oxygen species (ROS) and autophagy in cells, and the levels of ROS and autophagy are closely related to the occurrence and development of tumors. This paper reviewed the relationships among areca nut, intracellular ROS, and autophagy.
摘要
槟榔作为主要致癌物与口腔癌之间的关系已受到广泛关注。槟榔可改变细胞内活性氧（ROS）水平和自噬水平，而ROS水平和自噬水平与肿瘤的发生发展密切相关。本文综述了槟榔、细胞内ROS和自噬之间的关系。
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本文引用的文献
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2
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut.口腔黏膜下纤维化中的上皮萎缩由铜（II）和槟榔中的槟榔碱介导。
J Cell Mol Med. 2015 Oct;19(10):2397-412. doi: 10.1111/jcmm.12622. Epub 2015 Aug 6.
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Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes.槟榔暴露会增加牙龈成纤维细胞中促肿瘤细胞因子的分泌，这些细胞因子会引发口腔角质形成细胞中的DNA损伤。
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