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Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells.槟榔提取物诱导氧化应激和缺氧诱导因子上调导致口腔癌细胞自噬。
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Estimation of copper in saliva and areca nut products and its correlation with histological grades of oral submucous fibrosis.唾液和槟榔制品中铜的测定及其与口腔黏膜下纤维化组织学分级的相关性。
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Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation.槟榔在口腔癌发生中的多方面机制：从癌前状态到恶性转化的分子病理学
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引用本文的文献

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Research Achievements of Oral Submucous Fibrosis: Progress and Prospect.口腔黏膜下纤维性变的研究成果：进展与展望。
Biomed Res Int. 2021 Mar 18;2021:6631856. doi: 10.1155/2021/6631856. eCollection 2021.

本文引用的文献

1
Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling.槟榔提取物诱导的自噬有助于降低口腔鳞状细胞癌细胞中顺铂的毒性：活性氧/AMPK信号通路的作用
Int J Mol Sci. 2017 Mar 1;18(3):524. doi: 10.3390/ijms18030524.
2
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut.口腔黏膜下纤维化中的上皮萎缩由铜（II）和槟榔中的槟榔碱介导。
J Cell Mol Med. 2015 Oct;19(10):2397-412. doi: 10.1111/jcmm.12622. Epub 2015 Aug 6.
3
Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes.槟榔暴露会增加牙龈成纤维细胞中促肿瘤细胞因子的分泌，这些细胞因子会引发口腔角质形成细胞中的DNA损伤。
Int J Cancer. 2015 Dec 1;137(11):2545-57. doi: 10.1002/ijc.29636. Epub 2015 Jun 24.
4
Impacts of autophagy-inducing ingredient of areca nut on tumor cells.槟榔自噬诱导成分对肿瘤细胞的影响。
PLoS One. 2015 May 27;10(5):e0128011. doi: 10.1371/journal.pone.0128011. eCollection 2015.
5
Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components.槟榔成分诱导C3H10T1/2细胞的细胞毒性和转化
J Formos Med Assoc. 2016 Feb;115(2):108-12. doi: 10.1016/j.jfma.2015.01.004. Epub 2015 Feb 28.
6
ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms.活性氧与自噬：相互作用及分子调控机制
Cell Mol Neurobiol. 2015 Jul;35(5):615-21. doi: 10.1007/s10571-015-0166-x. Epub 2015 Feb 27.
7
mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions.mTOR信号通路在蛋白质翻译调控中的作用：对癌症发生及治疗干预的影响
Mol Biol Int. 2014;2014:686984. doi: 10.1155/2014/686984. Epub 2014 Nov 20.
8
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers.抑制自噬作为提高高LC3B三阴性乳腺癌化疗效率的新手段。
Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788.
9
Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.口腔鳞状细胞癌中自噬成分积累的免疫学意义
Cancer Sci. 2015 Jan;106(1):1-8. doi: 10.1111/cas.12559. Epub 2014 Dec 8.
10
ROS-dependent signal transduction.活性氧依赖性信号转导
Curr Opin Cell Biol. 2015 Apr;33:8-13. doi: 10.1016/j.ceb.2014.09.010. Epub 2014 Oct 8.

槟榔、细胞内活性氧与自噬之间的关系

[Relationship among areca nut, intracellular reactive oxygen species, and autophagy].

作者信息

Xu Zhi, Lü Feng-Yuan, Jiang Er-Hui, Zhao Xiao-Ping, Shang Zheng-Jun

机构信息

Dept. of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Feb 1;38(1):80-85. doi: 10.7518/hxkq.2020.01.014.

DOI:10.7518/hxkq.2020.01.014
PMID:32037771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7184295/
Abstract

The relationship between areca nut as a primary carcinogen and oral cancer has been widely concerned. Areca can change the levels of reactive oxygen species (ROS) and autophagy in cells, and the levels of ROS and autophagy are closely related to the occurrence and development of tumors. This paper reviewed the relationships among areca nut, intracellular ROS, and autophagy.

摘要

槟榔作为主要致癌物与口腔癌之间的关系已受到广泛关注。槟榔可改变细胞内活性氧（ROS）水平和自噬水平，而ROS水平和自噬水平与肿瘤的发生发展密切相关。本文综述了槟榔、细胞内ROS和自噬之间的关系。