Tetra-(-tolyl)antimony(III)-Containing Heteropolytungstates, [{(-tolyl)Sb}(-α-XWO)] (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity.

We have synthesized and structurally characterized three tetra-(-tolyl)antimony(III)-containing heteropolytungstates, [{(-tolyl)Sb}(-α-XWO)] [X = P (), As (), or Ge ()], in aqueous solution using conventional, one-pot procedures. The polyanions , , and were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of , , and were determined against four kinds of bacteria, including the two pathogenic bacteria strains, and . The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).