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肌浆网钙摄取与释放失衡：迈向钙触发心律失常和心脏损伤的第一步。

Unbalance Between Sarcoplasmic Reticulum Ca Uptake and Release: A First Step Toward Ca Triggered Arrhythmias and Cardiac Damage.

作者信息

Federico Marilén, Valverde Carlos A, Mattiazzi Alicia, Palomeque Julieta

机构信息

Centro de Investigaciones Cardiovasculares "Dr. Horacio E. Cingolani", CCT-La Plata/CONICET, Facultad de Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.

Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Buenos Aires, Argentina.

出版信息

Front Physiol. 2020 Jan 23;10:1630. doi: 10.3389/fphys.2019.01630. eCollection 2019.

DOI:10.3389/fphys.2019.01630
PMID:32038301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6989610/
Abstract

The present review focusses on the regulation and interplay of cardiac SR Ca handling proteins involved in SR Ca uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners' proteins. These control mechanisms guarantee a precise equilibrium between SR Ca reuptake and release. The review then discusses how disruption of this balance alters SR Ca handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.

摘要

本综述聚焦于参与肌浆网（SR）钙摄取和释放的心脏SR钙处理蛋白的调节及相互作用，即肌浆网钙ATP酶2（SERCa2）/受磷蛋白（PLN）和兰尼碱受体2（RyR2）。RyR2和SERCA2a/PLN均受到翻译后修饰和/或不同伴侣蛋白的高度调节。这些控制机制确保了SR钙再摄取和释放之间的精确平衡。该综述接着讨论了这种平衡的破坏如何改变SR钙处理，并可能成为心脏损伤和恶性心律失常的第一步。在综述的最后部分，以不同的心脏疾病为例阐述了这一概念，如糖尿病前期和糖尿病性心肌病、洋地黄中毒以及缺血再灌注损伤。

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2
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin-deficient mice.在tafazzin缺陷小鼠的左心室中，SERCA2a酪氨酸硝化与最大SERCA活性受损同时出现。
Physiol Rep. 2019 Aug;7(16):e14215. doi: 10.14814/phy2.14215.
3
Modulation of cardiac ryanodine receptor 2 by calmodulin.
心房颤动中钙通道的电生理机制及治疗潜力
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IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca Homeostasis.IRS2信号传导通过维持钙稳态来预防应激诱导的心律失常。
Circulation. 2024 Dec 10;150(24):1966-1983. doi: 10.1161/CIRCULATIONAHA.123.065048. Epub 2024 Sep 10.
5
Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic Mutation of Pediatric Restrictive Cardiomyopathy.诱导多能干细胞衍生的心肌细胞中致病性小儿限制型心肌病突变导致的舒张功能障碍。
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