Qi Jing, Chen Ling-Yun, Shen Xian-Juan, Ju Shao-Qing
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Center of Laboratory Medicine, Nantong Mental Health Center, Nantong, China.
Front Psychiatry. 2020 Jan 21;10:992. doi: 10.3389/fpsyt.2019.00992. eCollection 2019.
Psychiatric disorders impose a huge burden on individuals, families, and society. The repeat sequence is a member of the short interspersed nuclear element (SINE) family of mammalian genomes, however, its expression pattern and role in psychiatric disorders is unclear. The current paper aimed at determining the concentrations of in patients with schizophrenia (SZ), major depressive disorder (MDD), and alcohol-induced psychotic disorder (AIPD), and to further define the role and value of as a potential biomarker in psychiatric disorders. In this work, we found that the concentration of was considerably incremented in patients with SZ, and a significant difference existed between patients diagnosed with SZ and MDD or AIPD. ROC analysis also indicated that was effective in the complementary diagnosis of SZ, and differentially diagnosed between SZ patients and patients with MDD or AIPD. In addition, we found a positive relationship between the concentrations and interleukin-1β (IL-1β) in patients with SZ, MDD, and AIPD, and between the concentrations of and interleukin-18 (IL-18) in patients with SZ. Overall, the present work indicates that might be an innovative biomarker for diagnosing psychiatric disorders, and provides the basis for hypotheses about the pathophysiology of psychiatric disorders.
精神疾病给个人、家庭和社会带来了巨大负担。重复序列是哺乳动物基因组短散在核元件（SINE）家族的成员，然而，其在精神疾病中的表达模式和作用尚不清楚。本文旨在测定精神分裂症（SZ）、重度抑郁症（MDD）和酒精所致精神障碍（AIPD）患者体内的[具体物质]浓度，并进一步明确[具体物质]作为精神疾病潜在生物标志物的作用和价值。在这项研究中，我们发现SZ患者体内[具体物质]的浓度显著升高，且SZ患者与MDD或AIPD患者之间存在显著差异。ROC分析还表明，[具体物质]在SZ的辅助诊断中有效，且能对SZ患者与MDD或AIPD患者进行鉴别诊断。此外，我们发现SZ、MDD和AIPD患者体内[具体物质]浓度与白细胞介素-1β（IL-1β）之间存在正相关，SZ患者体内[具体物质]浓度与白细胞介素-18（IL-18）之间也存在正相关。总体而言，本研究表明[具体物质]可能是一种用于诊断精神疾病的创新性生物标志物，并为精神疾病病理生理学假说提供了依据。
