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河马通路与病毒感染

The Hippo Pathway and Viral Infections.

作者信息

Wang Zhilong, Lu Wanhang, Zhang Yiling, Zou Feng, Jin Zhigang, Zhao Tiejun

机构信息

College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China.

出版信息

Front Microbiol. 2020 Jan 23;10:3033. doi: 10.3389/fmicb.2019.03033. eCollection 2019.

Abstract

The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control, cell proliferation, cancer development, and virus-induced diseases. In this review, we summarize the current understanding of the biological feature and pathological role of the Hippo pathway, focusing particularly on current findings in the function of the Hippo pathway in virus infection and pathogenesis.

摘要

河马信号通路是一条新发现的肿瘤抑制通路,最初于近期研究发现河马信号通路在广泛的生物学过程中发挥关键作用,包括器官大小控制、细胞增殖、癌症发展以及病毒诱导的疾病。在本综述中,我们总结了目前对河马通路生物学特征和病理作用的理解,尤其关注河马通路在病毒感染和发病机制中功能的当前研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d667/6990114/171146b9146b/fmicb-10-03033-g001.jpg

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