Wang Yong-yu, Yu Wei, Zhou Bin
College of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yi Chuan. 2017 Jul 20;39(7):576-587. doi: 10.16288/j.yczz.17-039.
Cardiovascular diseases have become the leading cause of death in the world. Understanding the development of cardiovascular system and the pathogenesis of cardiovascular diseases will promote the generation of novel preventive and therapeutic strategy. The Hippo pathway is a recently identified signaling cascade that plays a critical role in organ size control, cell proliferation, apoptosis and fate determination of stem cells. Gene knockout and transgenic mouse models have revealed that the Hippo signaling pathway is involved in heart development, cardiomyocyte proliferation, apoptosis, hypertrophy and cardiac regeneration. The Hippo signaling pathway also regulates vascular development, differentiation and various functions of vascular cells. Dysregulation of the Hippo signaling pathway leads to different kinds of cardiovascular diseases, such as myocardial infarction, cardiac hypertrophy, neointima formation and atherosclerosis. In this review, we briefly summarize current research on the roles and regulation mechanisms of the Hippo signaling pathway in cardiovascular development and diseases.
心血管疾病已成为全球主要死因。了解心血管系统的发育以及心血管疾病的发病机制将推动新型预防和治疗策略的产生。Hippo信号通路是最近发现的一种信号级联反应，在器官大小控制、细胞增殖、细胞凋亡以及干细胞的命运决定中发挥关键作用。基因敲除和转基因小鼠模型表明，Hippo信号通路参与心脏发育、心肌细胞增殖、凋亡、肥大以及心脏再生。Hippo信号通路还调节血管发育、血管细胞的分化及多种功能。Hippo信号通路失调会导致各种心血管疾病，如心肌梗死、心脏肥大、新生内膜形成和动脉粥样硬化。在本综述中，我们简要总结了目前关于Hippo信号通路在心血管发育和疾病中的作用及调控机制的研究。
