LGR5（一种癌症干细胞标志物）在结直肠癌患者中的临床病理及预后意义
Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer.
作者信息
Ihemelandu Chukwuemeka, Naeem Aisha, Parasido Erika, Berry Deborah, Chaldekas Krysta, Harris Brent T, Rodriguez Olga, Albanese Christopher
机构信息
Program in Peritoneal Surface Oncology, MedStar Surgical Oncology, Department of Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Rd, NW Washington, DC 20007, USA.
Preclinical Imaging Research Laboratory, Center for Cell Reprogramming, Department of Oncology and Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Rd, NW Washington, DC 20007, USA.
出版信息
Colorectal Cancer. 2019 Nov 12;8(4):CRC11. doi: 10.2217/crc-2019-0009.
AIM
To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC).
PATIENTS & METHODS: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009-2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray.
RESULTS
LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival.
CONCLUSION
LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.
目的
分析富含亮氨酸重复序列的G蛋白偶联受体5（LGR5）这一癌症干细胞标志物在一组结直肠癌（CRC）患者中的临床病理及预后意义。
患者与方法
收集了2009年至2015年期间49例CRC患者的76个原发性或转移性肿瘤的福尔马林固定石蜡包埋组织块。通过组织芯片的免疫组化染色评估LGR5表达。
结果
LGR5在CRC组织样本中显著过表达，并且被发现是一个具有统计学意义的改善总生存期的独立预后标志物。
结论
结直肠癌中LGR5表达高于正常组织。LGR5是临床结局较好的独立预后标志物，可能作为CRC的潜在治疗靶点。
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