Kawa Nisrine, Lee Kachiu C, Anderson R Rox, Garibyan Lilit
Drs. Kawa, Anderson, and Garibyan are with the Wellman Center for Photomedicine at Massachusetts General Hospital and the Department of Dermatology at Harvard Medical School in Boston, Massachusetts.
Dr. Lee is with the Department of Dermatology at Brown University in Providence, Rhode Island.
J Clin Aesthet Dermatol. 2019 Oct;12(10):29-34. Epub 2019 Oct 1.
Onychomycosis is a challenging nail condition to treat. The gold standard treatment relies on long-term systemic therapy, which carries risks of potential side effects and drug interactions. Topical alternatives exist; however, treatment outcomes remain disappointing. In this article, we review newer topical formulations that are approved by the United States Food and Drug Administration, as well as other topical drugs that are still undergoing clinical trials. Lasers and energy-based devices have also been used for the treatment of onychomycosis; however, standardized parameters and clear treatment endpoints have yet to be specified. Currently, device-based therapies are considered as options for improving the cosmetic appearance of nails. The use of lasers to improve the penetration of topical antifungal treatments as possible combination treatments is also reviewed.
甲癣是一种治疗颇具挑战性的指甲病症。金标准治疗方法依赖长期的全身治疗，这存在潜在副作用和药物相互作用的风险。有局部治疗的替代方法；然而，治疗效果仍然令人失望。在本文中，我们综述了美国食品药品监督管理局批准的新型局部用药配方，以及其他仍在进行临床试验的局部用药。激光和基于能量的设备也已用于甲癣的治疗；然而，尚未确定标准化参数和明确的治疗终点。目前，基于设备的治疗方法被视为改善指甲外观的选择。本文还综述了使用激光来提高局部抗真菌治疗的渗透性作为可能的联合治疗方法。
