Queller Jenna N, Bhatia Neal
Dermatology Chief Resident at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Director of Clinical Dermatology, Therapeutics Clinical Research, San Diego, CA 92123, USA.
J Fungi (Basel). 2015 Aug 19;1(2):173-184. doi: 10.3390/jof1020173.
Onychomycosis is a fungal infection of the toenails or fingernails that can involve any component of the nail unit, including the matrix, bed, and plate. It is a common disorder that may be a reservoir for infection resulting in significant medical problems. Moreover, onychomycosis can have a substantial influence on one's quality of life. An understanding of the disorder and updated management is important for all health care professionals. Aside from reducing quality of life, sequelae of the disease may include pain and disfigurement, possibly leading to more serious physical and occupational limitations. Dermatologists, Podiatrists, and other clinicians who treat onychomycosis are now entering a new era when considering treatment options-topical modalities are proving more effective than those of the past. The once sought after concept of viable, effective, well-tolerated, and still easy-to-use monotherapy alternatives to oral therapy treatments for onychomycosis is now within reach given recent study data. In addition, these therapies may also find a role in combination and maintenance therapy; in order to treat the entire disease the practitioner needs to optimize these topical agents as sustained therapy after initial clearance to reduce recurrence or re-infection given the nature of the disease.
甲癣是一种发生于趾甲或指甲的真菌感染，可累及甲单位的任何组成部分，包括甲母质、甲床和甲板。它是一种常见疾病，可能成为导致严重医疗问题的感染源。此外，甲癣会对人的生活质量产生重大影响。了解这种疾病并掌握最新的治疗方法对所有医护人员都很重要。除了降低生活质量外，该病的后遗症可能包括疼痛和畸形，甚至可能导致更严重的身体和职业限制。皮肤科医生、足病医生以及其他治疗甲癣的临床医生在考虑治疗方案时，正进入一个新时代——局部治疗方法已被证明比过去更有效。鉴于最近的研究数据，曾经备受追捧的针对甲癣的可行、有效、耐受性良好且仍易于使用的口服治疗单一疗法替代品的概念现在已经可以实现。此外，这些疗法在联合治疗和维持治疗中也可能发挥作用；鉴于该疾病的性质，为了治疗整个疾病，从业者需要在初始清除后将这些局部药物优化为持续治疗，以减少复发或再次感染。
