Erdoğan Çağdaş, Tekin Selma, Ünlütürk Zeynep, Gedik Derya Korkut
Department of Neurology, University of Pamukkale, Denizli, Turkey.
Ideggyogy Sz. 2020 Jan 30;73(1-2):60-64. doi: 10.18071/isz.73.0060.
Myasthenia gravis (MG) and Guillain-Barré syndrome (GBS) are autoimmune disorders that may cause weakness in the extremities. The coexistence of MG and GBS in the same patient has rarely been reported previously. A 52-year-old male presenting with ptosis of the left eye that worsened with fatigue, especially toward evening, was evaluated in our outpatient department. His acetylcholine receptor antibody results were positive, supporting the diagnosis of MG. His medical history revealed a post-infectious acute onset of weakness in four extremities, difficulty in swallowing and respiratory failure, which was compatible with a myasthenic crisis; however, his nerve conduction studies and albuminocytologic dissociation at the time were compatible with GBS. With this case report, we aimed to mention this rare coincidental state, discuss possible diagnoses and review all other similar cases in the literature with their main features.
重症肌无力（MG）和吉兰 - 巴雷综合征（GBS）是可能导致四肢无力的自身免疫性疾病。此前，同一患者中MG和GBS并存的情况鲜有报道。一名52岁男性因左眼上睑下垂，且疲劳时加重，尤其是临近傍晚时加重，前来我院门诊就诊。他的乙酰胆碱受体抗体检测结果呈阳性，支持MG的诊断。他的病史显示，曾有感染后急性起病的四肢无力、吞咽困难和呼吸衰竭，这与重症肌无力危象相符；然而，他当时的神经传导研究和蛋白细胞分离现象与GBS相符。通过本病例报告，我们旨在提及这种罕见的巧合情况，讨论可能的诊断，并回顾文献中所有其他具有主要特征的类似病例。
