Azarnoosh M, Doostdar H
PhD, Department of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
MSc, Department of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
J Biomed Phys Eng. 2019 Dec 1;9(6):711-718. doi: 10.31661/jbpe.v0i0.400. eCollection 2019 Dec.
The importance of continuous monitoring along with rapid and accurate notification of changes in blood components such as hemoglobin concentration, especially in acute situations, encourages researchers to use non-invasive methods for measuring.
This study was aimed to investigate the correlation between hemoglobin concentration and photoplethysmogram (PPG) and the possibility of measuring it by an optical method.
In this applied study, a PPG signal was simultaneously recorded at four different wavelengths for thirty subjects who were referred to the laboratory for a hemoglobin concentration test. After calibrating the special recording probe with a standard pulse oximeter system and applying the required preprocessing on the obtained signals, the peak-to-peak value of PPG signals was extracted. Finally, the correlation between the peak-to-peak value of the signal at a certain wavelength and hemoglobin concentration was analyzed using Spearman and Pearson correlation for determining the process of changes in the data.
The results demonstrated that based on the normal distribution of data at 590 nm wavelength, there is a significantly negative correlation between a function of the signal peak slope and the hemoglobin concentration, with a Pearson coefficient of -0.787 (p<0.01). In addition, the investigation of rank correlation indicated a significantly negative correlation of -0.842 (p<0.01) using Spearman correlation analysis.
Considering the high correlation between hemoglobin concentration and PPG signal characteristics, optical methods can be used to develop a rapid, precise, clean and inexpensive method to measure hemoglobin concentration.
持续监测以及快速准确地通报血液成分变化（如血红蛋白浓度）的重要性，尤其在急性情况下，促使研究人员采用非侵入性测量方法。
本研究旨在调查血红蛋白浓度与光电容积脉搏波描记图（PPG）之间的相关性，以及通过光学方法测量血红蛋白浓度的可能性。
在这项应用研究中，为30名前往实验室进行血红蛋白浓度检测的受试者同时记录了四个不同波长下的PPG信号。在用标准脉搏血氧仪系统校准特殊记录探头并对获得的信号进行所需的预处理后，提取PPG信号的峰峰值。最后，使用Spearman和Pearson相关性分析特定波长下信号峰峰值与血红蛋白浓度之间的相关性，以确定数据变化过程。
结果表明，基于590nm波长数据的正态分布，信号峰值斜率函数与血红蛋白浓度之间存在显著负相关，Pearson系数为-0.787（p<0.01）。此外，秩相关性研究表明，使用Spearman相关性分析时，显著负相关系数为-0.842（p<0.01）。
考虑到血红蛋白浓度与PPG信号特征之间的高度相关性，光学方法可用于开发一种快速、精确、清洁且廉价的测量血红蛋白浓度的方法。
