Goldstein Stuart L
Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Front Pediatr. 2020 Jan 21;7:565. doi: 10.3389/fped.2019.00565. eCollection 2019.
Acute kidney injury (AKI) is independently associated with morbidity and mortality in critically ill neonates, children, adolescents, and young adults. AKI occurs commonly in this population, and the vast majority of published studies utilize only a serum creatinine based criteria for AKI diagnosis and staging. While urine output criteria have been a part of all AKI systematic and multidimensional AKI definitions for the past 15 years, oliguria based on these definitions is difficult to extract from the electronic health record. This manuscript reviews the published data regarding the impact of oliguria on patient outcomes, and the contribution of oliguria to % fluid overload and resultant changes in serum creatinine based epidemiology. The aim of this manuscript is to demonstrate that oliguria is an incredibly valuable biomarker for the management of patients with, or at-risk for, AKI.
急性肾损伤（AKI）与危重症新生儿、儿童、青少年及青年的发病率和死亡率独立相关。AKI在这一人群中很常见，并且绝大多数已发表的研究仅使用基于血清肌酐的标准来诊断和分期AKI。虽然在过去15年中，尿量标准一直是所有AKI系统性和多维AKI定义的一部分，但基于这些定义的少尿很难从电子健康记录中提取。本文综述了已发表的关于少尿对患者预后影响的数据，以及少尿对液体超负荷百分比的影响以及基于血清肌酐的流行病学的相应变化。本文旨在证明少尿是管理AKI患者或有AKI风险患者时非常有价值的生物标志物。
