Guinness L F, Sibandze S, McGrath E, Cornelis A L
Department of Obstetrics and Gynaecology, Mbabane Government Hospital, Swaziland.
Genitourin Med. 1988 Oct;64(5):294-7. doi: 10.1136/sti.64.5.294.
In a survey of 283 deliveries in Swaziland, active syphilis (positive results in the Treponema pallidum haemagglutination assay (TPHA) and the rapid plasma reagin (RPR) test) was found in 37 (13.1%) and possibly active infection (positive TPHA but negative RPR test results) in a further 87 (30.7%). The perinatal mortality of untreated mothers with active disease was 21.9% (7/32). The RPR test carried out antenatally by nurses had a sensitivity of 36% (13/36) and predictive accuracy of 48% (13/27). Awareness of this incidence of syphilis led to improved antenatal clinic measures and the prophylactic treatment of all newborn infants. More comprehensive serology is discussed and the prophylactic treatment of mothers considered. The need for health education aiming at safer sexual practices is of paramount importance in a society facing the arrival of the human immunodeficiency virus.
在对斯威士兰283例分娩进行的一项调查中，发现37例（13.1%）患有活动性梅毒（梅毒螺旋体血凝试验（TPHA）和快速血浆反应素（RPR）试验结果呈阳性），另有87例（30.7%）可能存在活动性感染（TPHA阳性但RPR试验结果阴性）。患有活动性疾病的未治疗母亲的围产期死亡率为21.9%（7/32）。护士在产前进行的RPR试验敏感性为36%（13/36），预测准确性为48%（13/27）。对梅毒发病率的了解促使改进了产前诊所措施，并对所有新生儿进行预防性治疗。文中讨论了更全面的血清学检查，并考虑了对母亲进行预防性治疗。在一个面临人类免疫缺陷病毒来袭的社会中，开展旨在促进更安全性行为的健康教育至关重要。
