Bignell C J, Mulcahy F M, Peaker S, Pullar T, Feely M P
Department of Genitourinary Medicine, General Infirmary, Leeds.
Genitourin Med. 1988 Oct;64(5):312-5. doi: 10.1136/sti.64.5.312.
Of 62 men with non-gonococcal urethritis who entered a study to assess compliance with treatment with oxytetracycline, only 33 could be evaluated. Traditional methods (interview and the absence of oxytetracycline in the urine) showed incomplete compliance in nine. Use of low dose phenobarbitone as a pharmacological marker showed incomplete compliance in a further five patients. In addition, phenobarbitone concentrations gave information on the extent to which individual patients had omitted treatment and provided direct, as opposed to circumstantial, evidence of good compliance by most (18) of those studied. Only three of the 33 patients whose compliance was assessed had evidence of continuing infection at follow up, and there was evidence of incomplete compliance in only one of these patients.
在62名患有非淋菌性尿道炎并参与一项评估土霉素治疗依从性研究的男性中，仅有33人可进行评估。传统方法（访谈以及尿液中无土霉素）显示9人依从性不完全。使用低剂量苯巴比妥作为药理学标记显示另有5名患者依从性不完全。此外，苯巴比妥浓度提供了有关个别患者漏服治疗程度的信息，并提供了直接证据（而非间接证据），表明大多数（18名）研究对象依从性良好。在评估了依从性的33名患者中，只有3人在随访时有持续感染的证据，且这些患者中只有1人有依从性不完全的证据。
