Mlodzik Natalia, Lukaszuk Krzysztof, Sieg Wlodzimierz, Jakiel Grzegorz, Smolarczyk Roman
Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, Poland, Poland.
Invicta Fertility Clinic, Gdansk, Poland.
Ginekol Pol. 2020;91(1):45-48. doi: 10.5603/GP.2020.0010.
Low biomass microbiome has an increasing importance in today's fertility studies. There are more and more indications for incorporating upper gynecological tract microbiome content in patients diagnostic and in vitro fertilization process, as doing so may help to evaluate chances for a positive outcome. An abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Furthermore it has been shown, that using molecular methods in addition to routine diagnostics may help diagnose chronic endometritis or even indicate cancerogenic changes. Understanding the significance of microbiome in endometrium may completely change therapeutic approach in treatment of this part of reproductive tract. Next generation sequencing (NGS) has allowed to isolate culturable and unculturable bacteria from female reproductive tract and is a cheaper and quicker alternative for other widely known and used methods.
低生物量微生物群落在当今的生育力研究中越来越重要。越来越多的迹象表明，在患者诊断和体外受精过程中纳入上生殖道微生物群内容，因为这样做可能有助于评估获得积极结果的机会。异常的子宫内膜微生物群与植入失败、妊娠丢失以及其他妇产科疾病有关。此外，研究表明，除常规诊断外使用分子方法可能有助于诊断慢性子宫内膜炎，甚至提示致癌性变化。了解微生物群落在子宫内膜中的意义可能会彻底改变对这部分生殖道的治疗方法。下一代测序（NGS）已能够从女性生殖道中分离出可培养和不可培养的细菌，并且是其他广为人知和使用的方法的更便宜、更快捷的替代方法。
