Research Department, Igenomix, Valencia, Spain; Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, California.
Reproductive Medicine Associates of New Jersey, Marlton, New Jersey; Thomas Jefferson University, Philadelphia, Pennsylvania.
Fertil Steril. 2017 Jul;108(1):32-39. doi: 10.1016/j.fertnstert.2017.05.034. Epub 2017 Jun 14.
Detection of bacteria with molecular techniques has enabled the study of low biomass microbiomes in tissues and organs previously considered sterile, such as the endometrium. Subsequently, an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obstetrical conditions. Further investigation of the reproductive tract microbiome will allow for a better understanding of bacterial communities' role in both physiology and pathophysiology, which in turn impacts the ability to achieve pregnancy and maintain a healthy pregnancy. Here we review the current literature that surrounds the endometrial microbiome and highlight the importance of assessing it as a future tool for improving reproductive outcomes in infertile patients.
利用分子技术检测细菌,使得人们能够研究以前被认为无菌的组织和器官中的低生物量微生物组,如子宫内膜。随后,异常的子宫内膜微生物组与着床失败、妊娠丢失以及其他妇科和产科疾病相关。进一步研究生殖道微生物组将有助于更好地了解细菌群落在生理和病理生理学中的作用,这反过来又影响了妊娠的能力和维持健康妊娠的能力。在这里,我们回顾了目前围绕子宫内膜微生物组的文献,并强调了评估其作为提高不孕患者生殖结局的未来工具的重要性。