体力活动对轻度至中度痴呆患者认知功能影响的个体差异。
Individual Differences in the Effects of Physical Activity on Cognitive Function in People with Mild to Moderate Dementia.
机构信息
Department of Geriatric Medicine & Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.
OLVG Hospital, Amsterdam, The Netherlands.
出版信息
J Alzheimers Dis. 2020;74(2):435-439. doi: 10.3233/JAD-190606.
Abstract
The aim of this study was to investigate whether the effect of physical activity on cognitive function in persons with dementia is moderated by patient characteristics as Apolipoprotein E and dementia type. We included 101 individuals with dementia and calculated the reliable change index to determine the change in global cognition, executive function, episodic memory, working memory, and processing speed before and after a 12-week exercise training. We found a higher treatment-related benefit in episodic memory in persons with non-Alzheimer's disease compared to persons with Alzheimer's disease, and in executive function in individuals with better baseline cognitive function.
摘要
本研究旨在探讨运动对痴呆患者认知功能的影响是否受载脂蛋白 E 和痴呆类型等患者特征的调节。我们纳入了 101 名痴呆患者，并计算了可靠变化指数，以确定在 12 周运动训练前后整体认知、执行功能、情景记忆、工作记忆和处理速度的变化。我们发现，与阿尔茨海默病患者相比，非阿尔茨海默病患者的情景记忆以及认知功能基线较好的个体的执行功能的治疗相关获益更高。
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