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本文引用的文献

1
The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial.通过健身游戏在痴呆症患者中寻求体力活动和认知刺激的协同作用：一项随机对照试验。
Alzheimers Res Ther. 2019 Jan 5;11(1):3. doi: 10.1186/s13195-018-0454-z.
2
Effective multicomponent interventions in comparison to active control and no interventions on physical capacity, cognitive function and instrumental activities of daily living in elderly people with and without mild impaired cognition - A systematic review and network meta-analysis.针对认知轻度受损和无认知轻度受损的老年人，比较身体能力、认知功能和日常生活工具性活动方面，有效的多组分干预与积极对照和无干预的效果 - 系统评价和网络荟萃分析。
Ageing Res Rev. 2018 Aug;45:1-14. doi: 10.1016/j.arr.2018.04.002. Epub 2018 Apr 18.
3
Aerobic exercise promotes executive functions and impacts functional neural activity among older adults with vascular cognitive impairment.有氧运动可改善血管性认知障碍老年人的执行功能，并影响其功能神经活动。
Br J Sports Med. 2018 Feb;52(3):184-191. doi: 10.1136/bjsports-2016-096846. Epub 2017 Apr 21.
4
The effect of an interactive cycling training on cognitive functioning in older adults with mild dementia: study protocol for a randomized controlled trial.交互式骑行训练对轻度痴呆老年人认知功能的影响：一项随机对照试验的研究方案
BMC Geriatr. 2017 Mar 21;17(1):73. doi: 10.1186/s12877-017-0464-x.
5
The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials.体育活动对痴呆症患者认知功能的影响：一项随机对照试验的荟萃分析。
Ageing Res Rev. 2016 Jan;25:13-23. doi: 10.1016/j.arr.2015.11.005. Epub 2015 Nov 28.
6
Exercise programs for people with dementia.针对痴呆症患者的运动项目。
Cochrane Database Syst Rev. 2015 Apr 15;2015(4):CD006489. doi: 10.1002/14651858.CD006489.pub4.
7
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.中年时期的休闲体育活动与痴呆症和阿尔茨海默病的风险
Lancet Neurol. 2005 Nov;4(11):705-11. doi: 10.1016/S1474-4422(05)70198-8.
8
Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study.身体活动、载脂蛋白E基因型与痴呆风险：心血管健康认知研究的结果
Am J Epidemiol. 2005 Apr 1;161(7):639-51. doi: 10.1093/aje/kwi092.

体力活动对轻度至中度痴呆患者认知功能影响的个体差异。

Individual Differences in the Effects of Physical Activity on Cognitive Function in People with Mild to Moderate Dementia.

机构信息

Department of Geriatric Medicine & Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.

OLVG Hospital, Amsterdam, The Netherlands.

出版信息

J Alzheimers Dis. 2020;74(2):435-439. doi: 10.3233/JAD-190606.

DOI:10.3233/JAD-190606
PMID:32039840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7175929/
Abstract

The aim of this study was to investigate whether the effect of physical activity on cognitive function in persons with dementia is moderated by patient characteristics as Apolipoprotein E and dementia type. We included 101 individuals with dementia and calculated the reliable change index to determine the change in global cognition, executive function, episodic memory, working memory, and processing speed before and after a 12-week exercise training. We found a higher treatment-related benefit in episodic memory in persons with non-Alzheimer's disease compared to persons with Alzheimer's disease, and in executive function in individuals with better baseline cognitive function.

摘要

本研究旨在探讨运动对痴呆患者认知功能的影响是否受载脂蛋白 E 和痴呆类型等患者特征的调节。我们纳入了 101 名痴呆患者，并计算了可靠变化指数，以确定在 12 周运动训练前后整体认知、执行功能、情景记忆、工作记忆和处理速度的变化。我们发现，与阿尔茨海默病患者相比，非阿尔茨海默病患者的情景记忆以及认知功能基线较好的个体的执行功能的治疗相关获益更高。