Saito H, Kimura K, Takamiya M, Yamamoto K, Ohta M, Yamagami H, Kamiya T
Department of Radiology, National Cardiovascular Center, Osaka, Japan.
Invest Radiol. 1988 Dec;23(12):910-3. doi: 10.1097/00004424-198812000-00006.
Twenty-six patients with Kawasaki disease were observed in a prospective crossover study to compare coronary arteriography with a nonionic low-osmolar contrast medium, iopamidol 370 mgI/mL, and with an ionic low-osmolar contrast medium, ioxaglate 320 mgI/mL. A slight heart rate change and no severe arrhythmia during coronary arteriography were observed with both agents. Electrocardiographically, QTc elongation and ST-T changes were marked in ioxaglate and minimal in iopamidol. No ventricular fibrillation occurred with either agent. Both contrast media provided adequate visualization for the diagnosis of Kawasaki disease, but the contrast of the images and the visualization of details were better with iopamidol than with ioxaglate. Iopamidol seems to be superior to ioxaglate in pediatric coronary arteriography.
在一项前瞻性交叉研究中，对26例川崎病患者进行观察，比较使用非离子型低渗造影剂碘帕醇（370mgI/mL）和离子型低渗造影剂碘克沙醇（320mgI/mL）进行冠状动脉造影的情况。两种造影剂在冠状动脉造影期间均观察到轻微的心率变化，未出现严重心律失常。心电图方面，碘克沙醇组QTc延长和ST-T改变明显，碘帕醇组则最小。两种造影剂均未发生心室颤动。两种造影剂均能为川崎病的诊断提供足够的显影，但碘帕醇造影图像的对比度和细节显示优于碘克沙醇。在儿科冠状动脉造影中，碘帕醇似乎优于碘克沙醇。
