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Is PD-1 blockade a potential therapy for HBV?

作者信息

Féray Cyrille, López-Labrador F Xavier

机构信息

Centre Hépatobiliaire, Paul Brousse Hospital, Inserm-Paris Sud Research Unit 1193, University Paris Sud, Villejuif, Paris, France.

Virology Laboratory Genomics and Health Area FISABIO - Public Health, Generalitat Valenciana, Valencia, Spain.

出版信息

JHEP Rep. 2019 Aug 28;1(3):142-144. doi: 10.1016/j.jhepr.2019.07.007. eCollection 2019 Sep.

DOI:10.1016/j.jhepr.2019.07.007
PMID:32040093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7001582/
Abstract
摘要

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Is PD-1 blockade a potential therapy for HBV?程序性死亡受体1（PD-1）阻断疗法是治疗乙型肝炎病毒（HBV）的潜在疗法吗？
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2
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Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation.PD-1 阻断在非活动携带者患者中恢复 HBV 特异性 CD8+ T 细胞功能与 T 细胞分化有关。
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PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients.程序性死亡受体1（PD-1）上调与慢性乙型肝炎患者的乙肝病毒特异性T细胞功能障碍有关。
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本文引用的文献

1
Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.尼伏单抗联合或不联合治疗性疫苗治疗病毒抑制慢性乙型肝炎的抗 PD-1 阻断：一项初步研究。
J Hepatol. 2019 Nov;71(5):900-907. doi: 10.1016/j.jhep.2019.06.028. Epub 2019 Jul 12.
2
HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications.HBV 免疫治疗：从分子机制到临床应用。
Int J Mol Sci. 2019 Jun 5;20(11):2754. doi: 10.3390/ijms20112754.
3
Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis.纳武利尤单抗治疗晚期肝细胞癌：索拉非尼经治亚洲人群队列分析。
J Hepatol. 2019 Sep;71(3):543-552. doi: 10.1016/j.jhep.2019.05.014. Epub 2019 Jun 7.
4
Is the function of the HBeAg really unknown?HBeAg 的功能真的未知吗？
Hum Vaccin Immunother. 2019;15(9):2187-2191. doi: 10.1080/21645515.2019.1607132. Epub 2019 May 9.
5
A global scientific strategy to cure hepatitis B.全球治愈乙型肝炎的科学策略。
Lancet Gastroenterol Hepatol. 2019 Jul;4(7):545-558. doi: 10.1016/S2468-1253(19)30119-0. Epub 2019 Apr 10.
6
Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.适应性免疫耐受的崩溃导致 HBsAg-tg 小鼠发生肝细胞癌。
Nat Commun. 2019 Jan 15;10(1):221. doi: 10.1038/s41467-018-08096-8.
7
Success of immune checkpoint blockade therapies - mechanisms and implications for hepatology.免疫检查点阻断疗法的成功——机制及其对肝病学的意义
Z Gastroenterol. 2019 Jan;57(1):74-86. doi: 10.1055/a-0805-6936. Epub 2019 Jan 14.
8
Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Neurologic Toxicity: Illustrative Case and Review of the Literature.免疫检查点抑制剂相关神经毒性的诊断和治疗：病例举例与文献复习。
Oncologist. 2019 Apr;24(4):435-443. doi: 10.1634/theoncologist.2018-0359. Epub 2018 Nov 27.
9
Immune checkpoint inhibitors and cardiovascular toxicity.免疫检查点抑制剂与心血管毒性。
Lancet Oncol. 2018 Sep;19(9):e447-e458. doi: 10.1016/S1470-2045(18)30457-1.
10
PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.PD-1 阻断部分恢复慢性乙型肝炎感染中功能失调的病毒特异性 B 细胞。
J Clin Invest. 2018 Oct 1;128(10):4573-4587. doi: 10.1172/JCI121957. Epub 2018 Aug 7.