瑞典扁桃体癌患者与治疗相关的健康相关生活质量及与普通人群生活质量的比较
Health-related quality of life among tonsillar carcinoma patients in Sweden in relation to treatment and comparison with quality of life among the population.
作者信息
Adnan Ali, Högmo Anders, Sjödin Helena, Gebre-Medhin Maria, Laurell Göran, Reizenstein Johan, Farnebo Lovisa, Norberg Lena S, Notstam Isak, Holmberg Erik, Cange Hedda H, Hammerlid Eva
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden.
出版信息
Head Neck. 2020 May;42(5):860-872. doi: 10.1002/hed.26064. Epub 2020 Feb 10.
BACKGROUND
The health-related quality of life (HRQOL) of tonsillar carcinoma survivors was explored to investigate any HRQOL differences associated with tumor stage and treatment. The survivors' HRQOL was also compared to reference scores from the population.
METHODS
In this exploratory cross-sectional study patients were invited 15 months after their diagnosis and asked to answer two quality of life questionnaires (EORTC QLQ- C30, EORTC QLQ- HN35), 405 participated.
RESULTS
HRQOL was associated with gender, with males scoring better than females on a few scales. Patients' HRQOL was more associated with treatment than tumor stage. Patients' HRQOL was worse than that in an age- and sex-matched reference group from the normal population, the largest differences were found for problems with dry mouth followed by problems with sticky saliva, senses, swallowing and appetite loss.
CONCLUSIONS
The tonsillar carcinoma patients had a worse HRQOL compared to the general population one year after treatment.
背景
探讨扁桃体癌幸存者的健康相关生活质量（HRQOL），以调查与肿瘤分期和治疗相关的任何HRQOL差异。还将幸存者的HRQOL与人群参考分数进行了比较。
方法
在这项探索性横断面研究中，患者在诊断后15个月被邀请，并被要求回答两份生活质量问卷（EORTC QLQ-C30、EORTC QLQ-HN35），405人参与。
结果
HRQOL与性别相关，在一些量表上男性得分高于女性。患者的HRQOL与治疗的相关性大于与肿瘤分期的相关性。患者的HRQOL比来自正常人群的年龄和性别匹配参考组差，口干问题差异最大，其次是唾液黏稠、感官、吞咽和食欲丧失问题。
结论
与一般人群相比，扁桃体癌患者在治疗一年后的HRQOL较差。
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