Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Int J Eat Disord. 2020 May;53(5):532-536. doi: 10.1002/eat.23243. Epub 2020 Feb 10.
Gastrointestinal (GI) symptoms appear frequently in patients with anorexia nervosa (AN), but the associations between psychopathological, GI, and eating disorder (ED) symptoms remain unclear. This study aimed to determine the relationships of GI complaints with psychopathological measures, ED symptoms, and body mass index (BMI) in patients with AN.
Thirty outpatients with AN aged >16 years were included. Psychopathological measures (Symptom Checklist-90-Revised, Beck Depression Inventory-II, and Beck Anxiety Inventory), ED symptoms (Eating Disorder Examination Questionnaire), ED-associated impairment (Clinical Impairment Assessment Questionnaire), GI complaints (Irritable Bowel Syndrome Severity Scoring System [IBS-SSS]), and BMI were assessed prior to starting treatment, and correlation and multiple regression analyses were applied to data from 19 patients.
IBS-symptoms were significantly correlated only with ED symptoms (r = 0.583, p = .009) and somatization (r = 0.666, p = .002). Multiple regression analysis revealed that somatization significantly predicted worse IBS symptoms (beta = 0.5, p = .04), while ED symptoms did not.
Higher IBS-SSS scores were associated with higher severities of other somatic complaints. GI complaints and somatization should be addressed in treatments for AN in order to prevent these factors impeding the establishment of healthy eating patterns.
ClinicalTrials.gov Identifier: NCT02745067.
厌食症（AN）患者常出现胃肠道（GI）症状，但心理病理、GI 和饮食障碍（ED）症状之间的关系尚不清楚。本研究旨在确定 AN 患者的 GI 主诉与心理病理测量、ED 症状和体重指数（BMI）的关系。
纳入 30 名年龄>16 岁的 AN 门诊患者。在开始治疗前评估心理病理测量（症状清单-90 修订版、贝克抑郁量表二和贝克焦虑量表）、ED 症状（饮食障碍检查问卷）、ED 相关损害（临床损伤评估问卷）、GI 主诉（肠易激综合征严重程度评分系统[IBS-SSS]）和 BMI，并对 19 名患者的数据进行了相关和多元回归分析。
IBS 症状仅与 ED 症状（r = 0.583，p =.009）和躯体化（r = 0.666，p =.002）显著相关。多元回归分析显示，躯体化显著预测更严重的 IBS 症状（β=0.5，p =.04），而 ED 症状则不然。
更高的 IBS-SSS 评分与其他躯体主诉的严重程度更高相关。在治疗 AN 时应解决 GI 主诉和躯体化问题，以防止这些因素阻碍健康饮食模式的建立。
ClinicalTrials.gov 标识符：NCT02745067。
