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住院溃疡性结肠炎患者的管理:内科-外科难题

The Management of the Hospitalized Ulcerative Colitis Patient: the Medical-Surgical Conundrum.

作者信息

Carvello Michele, Watfah Joseph, Włodarczyk Marcin, Spinelli Antonino

机构信息

Colon and Rectal Surgery Division, Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, Rozzano, 20089, Milan, Italy.

Department of General Surgery, Northwick Park Hospital, London, UK.

出版信息

Curr Gastroenterol Rep. 2020 Feb 10;22(3):11. doi: 10.1007/s11894-020-0750-1.

Abstract

PURPOSE OF REVIEW

In this study, we present the evidence-based management for patients hospitalized for ulcerative colitis (UC) with a special focus on the synergic approach of the two key actors of the inflammatory bowel disease multidisciplinary team (IBD-MDT): gastroenterologist and surgeon.

RECENT FINDINGS

Focused treatment by a specialized IBD-MDT and early involvement of the colorectal surgeon in the management of hospitalized UC patients is advocated. The colectomy rate has not changed over the years. Moreover, delayed surgery after admission is burden by increase complication and mortality rates. Thus, it is pivotal to identify the patients who are likely to undergo surgery, by mean of predictors of outcome, and not to prolong ineffective medical treatment. The perfect timing based on clinical close monitoring is crucial. Up to 25% of patients with ulcerative colitis (UC) may require hospitalization. The aim of admission is to evaluate severity of the disease, exclude infections and establish proper treatment while monitoring the response. During admission, the patient has to be closely observed for the possible development of toxic megacolon or perforation, which should prompt emergency colectomy. Up to 30% of UC patients will fail to respond to initial intravenous corticosteroid. Non-responder or partial responder to medical therapy should be evaluated for timely surgery or could be considered for rescue medical therapy.

摘要

综述目的

在本研究中,我们介绍了针对溃疡性结肠炎(UC)住院患者的循证管理,特别关注炎症性肠病多学科团队(IBD-MDT)的两个关键成员:胃肠病学家和外科医生的协同方法。

最新发现

提倡由专业的IBD-MDT进行针对性治疗,并让结直肠外科医生尽早参与住院UC患者的管理。多年来结肠切除术的发生率没有变化。此外,入院后延迟手术会因并发症和死亡率增加而负担加重。因此,通过预后预测指标来识别可能接受手术的患者并避免延长无效的药物治疗至关重要。基于临床密切监测的最佳时机至关重要。高达25%的溃疡性结肠炎(UC)患者可能需要住院治疗。入院目的是评估疾病严重程度、排除感染并在监测反应的同时确立适当治疗。住院期间,必须密切观察患者是否可能发生中毒性巨结肠或穿孔,一旦出现应立即进行急诊结肠切除术。高达30%的UC患者对初始静脉注射皮质类固醇无反应。对药物治疗无反应或部分反应者应评估是否及时手术,或可考虑进行挽救性药物治疗。

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